百日咳患者血清25-羟维生素D水平研究  

Serum 25-hydroxyvitamin D levels in patients with pertussis

作　　者：唐丽 彭晓康[1] 李瑞娜[1] 舒畅 刘攀 刘希 王策 王蓓[2] 张书婉 张婕[3] 王增国[2] 刘小乖[1] TANG Li;PENG Xiaokang;LI Ruina;SHU Chang;LIU Pan;LIU Xi;WANG Ce;WANG Bei;ZHANG Shuwan;ZHANG Jie;WANG Zengguo;LIU Xiaoguai(The Third Department of Infectious Diseases,Xi'an Children's Hospital,Xi'an,Shaanxi 710003,China;Laboratory Department,Xi'an Children's Hospital,Xi'an,Shaanxi 710003,China;Child Healthcare Department,Xi'an Children's Hospital,Xi'an,Shaanxi 710003,China)

机构地区：[1]西安市儿童医院感染三科,陕西西安710003 [2]西安市儿童医院检验科,陕西西安710003 [3]西安市儿童医院儿保科,陕西西安710003

出　　处：《热带医学杂志》2024年第3期360-364,共5页Journal of Tropical Medicine

基　　金：国家自然科学基金面上项目(82172312);陕西省卫生健康科研基金项目(2021E002);西安市科技计划项目(20YXYJ0006(1));西安市儿童医院院级课题项目(2020C03)。

摘　　要：目的了解百日咳患者25-羟维生素D[25(OH)D]水平,探讨25(OH)D水平与百日咳的相关性。方法纳入2021年1-12月于西安市儿童医院确诊的255例百日咳患者(百日咳组),同期健康体检的765名儿童为健康对照组,其中百日咳患者根据是否重症分为普通百日咳组(n=244)和重症百日咳组(n=11),检测各组血清25(OH)D水平,进一步按照性别、年龄、季节分析百日咳与血清25(OH)D的相关性。结果百日咳组与健康对照组在性别、年龄以及季节分布差异均无统计学意义(P均>0.05)。百日咳组25(OH)D水平[20.73(10.96,35.62)ng/mL]低于健康对照组[29.00(20.09,45.66)ng/mL],差异有统计学意义(Z=-7.643,P<0.05)。不同性别、年龄段百日咳组25(OH)D水平显著低于健康对照组,差异均有统计学意义(P均<0.05);秋季、冬季百日咳组25(OH)D水平均显著低于健康对照组,差异均有统计学意义(Z=-8.273、-8.904,P均<0.05);春季、夏季百日咳组与健康对照组25(OH)D水平比较差异均无统计学意义(Z=-0.868、-0.292,P均>0.05)。百日咳组与健康对照组疫苗接种剂次构成比比较差异有统计学意义(χ^(2)=12.489,P<0.05)。百日咳发病年龄呈双高峰,分别为<1岁、6~8岁。重症百日咳组年龄低于普通百日咳组,差异有统计学意义(Z=-3.972,P<0.05);两组25(OH)D水平差异无统计学意义(Z=-1.783,P>0.05)。结论百日咳患者维生素D水平普遍较低,而维生素D水平降低可能导致百日咳杆菌暴露后的机体易感性增加。Objective To investigate the 25-hydroxyvitamin D[25(OH)D]level of pertussis patients and explore the correlation between 25(OH)D level and pertussis.Methods A total of 255 pertussis patients diagnosed in the Xi ' an Children ' s Hospital from January to December 2021 were enrolled as the pertussis group and 765 healthy children who underwent physical examination during the same period were enrolled as the healthy control group.According to the severity of the disease,the patients were divided into the common pertussis group(n=244)and the severe pertussis group(n=11).The serum 25(OH)D levels of each group were detected,and the correlation between pertussis and serum 25(OH)D was further analyzed according to gender,age and season.Results There was no significant difference in sex,age and season distribution between pertussis group and healthy control group(all P>0.05).25(OH)D level of pertussis group[20.73(10.96,35.62)ng/mL]was significantly lower than that of healthy control group [29.00(20.09,45.66)ng/mL],the difference was statistically significant(Z=-7.643,P<0.05).The serum 25(OH)D level in the pertussis group was lower than that in healthy control group in different gender and age,the differences were statistically significant(all P<0.05).The 25(OH)D levels in the pertussis group in autumn and winter were significantly lower than those in the healthy control group,and the differences were statistically significant(Z=-8.273,-8.904,both P<0.05);there was no statistically significant difference in 25(OH)D levels between the pertussis group and the healthy control group in spring and summer(Z=-0.868,-0.292,both P>0.05).There was a statistically significant difference in the composition ratio of vaccination doses between the pertussis group and the healthy control group(χ^(2)=12.489,P<0.05).The age of onset of pertussis had two peaks,which were less than 1 year old and 6 to 8 years old.The age of the severe pertussis group was lower than that of the common pertussis group,and the difference was statistically signi

关 键 词：百日咳 25-羟维生素D 儿童 

分 类 号：R516.6[医药卫生—内科学]