肾安方对早期糖尿病肾病(气阴两虚兼血瘀证)患者尿微量白蛋白、微炎症状态及胰岛素抵抗的影响  

Effects of shenan decoction on urinary microalbumin,microinflammatory state and insulin resistance in patients with early diabetic nephropathy(qi and yin deficiency and blood stasis syndrome)

作　　者：吕艳丽 张卜 胡娟[1] LV Yanli;ZHANG Bu;HU Juan(Huangshi Aikang Hospital,Huangshi Hubei 453000,China)

机构地区：[1]黄石市爱康医院,湖北黄石453000

出　　处：《四川中医》2024年第2期138-141,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：湖北省卫生健康委联合基金项目(编号:WJ2019H470)。

摘　　要：目的:探究肾安方对早期糖尿病肾病(气阴两虚兼血瘀证)患者尿微量白蛋白(m-UALB)、微炎症状态、胰岛素抵抗的影响。方法:选取2020年10月~2022年10月我院就诊94例糖尿病肾病(气阴两虚兼血瘀证)患者作为观察对象,使用区组随机化法分为观察组和对照组,每组各47例。对照组采取常规治疗措施,观察组在其基础上加服肾安方。比较两组治疗前、治疗3个月后中医证候积分、尿蛋白水平[m-UALB、尿白蛋白/尿肌酐(UACR)]、血清炎症指标[白细胞介素-6(IL-6)、白细胞介素-22(IL-22)、白细胞介素-1β(IL-1β)]、胰岛素抵抗[空腹胰岛素(FIN)、空腹血糖(FBG)]、肾功能[血肌酐(SCr)、血尿素(BUN)]的变化。结果:治疗3个月后,两组中医证候积分、m-UALB、UACR、血清IL-6、IL-22、IL-1β、FIN、FBG、SCr、BUN水平均显著降低,且观察组低于对照组(P均<0.05)。结论:肾安方可有效改善早期糖尿病肾病患者尿蛋白和胰岛素对抗症状,抑制炎性介质产生,具有临床推广价值。Objective:To explore the effects of shenan decoction on urinary microalbumin(m-UALB),microinflammatory state and insulin resistance in patients with early diabetic nephropathy(qi and yin deficiency and blood stasis syndrome).Methods:94patients with diabetic nephropathy(qi and yin deficiency and blood stasis syndrome)treated in the hospital from October 2020to October 2022were selected as observation subjects,and were divided into observation group and control group by block randomized method,with 47cases in each group.The control group was given conventional treatment measure,and the observation group was supplemented with shenan decoction on this basis.TCM syndromes scores,urinary proteins levels[m-UALB,urinary albumin creatinine ratio(UACR)],serum inflammatory indicators[interleukin-6(IL-6),interleukin-22(IL-22),interleukin-1β(IL-1β)],insulin resistance[fasting insulin(FIN),fasting blood glucose(FBG)]and renal function[serum creatinine(SCr),blood urea nitrogen(BUN)]were compared between the two groups before treatment and after 3months of treatment.Results:After 3months of treatment,the TCM syndromes scores and levels of m-UALB,UACR,serum IL-6,IL-22,IL-1β,FIN,FBG,SCr and BUN in both groups were significantly decreased,and the scores and levels in observation group were lower than those in control group(P<0.05).Conclusion:shenan decoction can effectively improve the urinary proteins and insulin resistance symptoms,and inhibit the productions of inflammatory mediators in patients with early diabetic nephropathy,and it has the clinical promotion value.

关 键 词：肾安方 糖尿病肾病 气阴两虚 血瘀 m-UALB 

分 类 号：R587.2[医药卫生—内分泌]