止血组方加减治疗功能失调性子宫出血患者的效果及对性激素水平的影响  

Effect of modified hemostatic formula on patients with dysfunctional uterine bleeding and its influence on sex hormone level

作　　者：吴雅楠[1] 辛兴涛 WU Yanan;XIN Xingtao(Department of Traditional Chinese Medicine,General Hospital of North China Petroleum Administration,Renqiu Hebei 062552,China;The Eighth People's Hospital of Hebei Province,Shijiazhuang Hebei 050011,China)

机构地区：[1]华北石油管理局总医院中医科,河北任丘062552 [2]河北省第八人民医院普外肛肠科,河北石家庄050011

出　　处：《四川中医》2024年第2期175-178,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：河北中医药管理局科研项目(编号:2018516,不同年龄段功能失调性子宫出血的体质判断和止血组方对其的疗效观察)。

摘　　要：目的:探讨止血组方加减治疗功能失调性子宫出血(DUB)患者的效果及对性激素水平的影响。方法:选择2021年9月~2022年9月来本院就诊的DUB患者150例进行研究,用随机数表法将患者分两组各75例。对照组给予妈富隆治疗,观察组给予止血组方加减治疗。治疗3个月经周期,比较两组疗效,记录治疗前后月经量、子宫内膜厚度、血红蛋白及性激素[(雌二醇(E_(2))、孕酮(P)、促卵泡生产数(FSH)、促黄体生成素(LH)]水平变化,并统计患者不良反应。结果:观察组的总有效率(93.33%)高于对照组(77.33,P<0.05);治疗后,两组的月经量、子宫内膜厚度均降低,且观察组低于对照组,而血红蛋白升高,观察组高于对照组(P<0.05);治疗后,两组的E2、P水平升高,观察组高于对照组,而FSH、LH将治疗前降低,观察组低于对照组(P<0.05);观察组不良反应发生率为4.00%,明显低于对照组(17.33%,P<0.05)。结论:止血组方加减治疗DUB效果理想,可有效调节性激素水平,加速病情优化,具有较高的用药安全性,可在临床推广运用。Objective:To explore the effect of modified hemostatic formula on patients with dysfunctional uterine bleeding(DUB)and its influence on sex hormone level.Methods:150patients with DUB from September 2021to September 2022were selected for the study,and 75patients were divided into two groups by random number table.The control group was treated with Mafulong,and the observation group was treated with hemostatic group.After treatment for 3menstrual cycles,compare the curative effect of the two groups,record the changes of menstrual volume,endometrial thickness,hemoglobin and sex hormone[estradiol(E_(2)),progesterone(P),follicle stimulating hormone(FSH),luteinizing hormone(LH)]levels before and after treatment,and count the adverse reactions of patients.Results:The total effective rate of the observation group(93.33%)was higher than that of the control group(77.33,P<0.05);after treatment,the menstrual volume and endometrial thickness of the two groups decreased,and the observation group was lower than the control group,while the hemoglobin increased,and the observation group was higher than the control group(P<0.05);after treatment,the level of E2and P in the two groups increased,and the level of FSH and LH in the observation group was higher than that in the control group,while the level of FSH and LH in the observation group was lower than that in the control group(P<0.05);the incidence of adverse reactions in the observation group was 4.00%,significantly lower than that in the control group(17.33%,P<0.05).Conclusion:The modified hemostatic formula has an ideal effect on the treatment of DUB,can effectively regulate the level of sex hormone,accelerate the optimization of the condition,and has a high drug safety,which can be widely used in clinical practice.

关 键 词：功能失调性子宫出血 止血组方加减 妈富隆 性激素 疗效 不良反应 

分 类 号：R711.52[医药卫生—妇产科学]