从快照到电影:捕捉单核苷酸分辨率的真核生物转录起始过程  

From snapshots to a movie:Capturing eukaryotic transcription initiation at single-nucleotide resolution

作　　者：尚雪莹 徐从玲 陈飞 Xue-Ying Shang;Congling Xu;Fei Xavier Chen(Fudan University Shanghai Cancer Center,Institutes of Biomedical Sciences,Shanghai Key Laboratory of Radiation Oncology,Shanghai Key Laboratory of Medical Epigenetics,Shanghai Medical College of Fudan University,Shanghai 200032,China;Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation,Clinical Research Center for Anesthesiology and Perioperative Medicine,Translational Research Institute of Brain and Brain-Like Intelligence,Shanghai Fourth People’s Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China)

机构地区：[1]Fudan University Shanghai Cancer Center,Institutes of Biomedical Sciences,Shanghai Key Laboratory of Radiation Oncology,Shanghai Key Laboratory of Medical Epigenetics,Shanghai Medical College of Fudan University,Shanghai 200032,China [2]Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation,Clinical Research Center for Anesthesiology and Perioperative Medicine,Translational Research Institute of Brain and Brain-Like Intelligence,Shanghai Fourth People’s Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China

出　　处：《Science Bulletin》2024年第7期853-855,共3页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(32070636)。

摘　　要：The process of transcription is generally delineated into three sequential phases:initiation,elongation,and termination.The transition between these phases,particularly from initiation to elongation,requires substantial conformational and compositional reconfigurations within the transcription machinery to enable functional switches.Transcription initiation is characterized by the assembly of a preinitiation complex(PIC).

关 键 词：figuration enable TERMINATION 

分 类 号：Q75[生物学—分子生物学]