精原干细胞命运调控的研究进展  

Advances in Spermatogonial Stem Cell Fate Regulation

作　　者：朱立发 孙嘉辰 吴鑫[1] ZHU Lifa;SUN Jiachen;WU Xin(State Key Laboratory of Reproductive Medicine and Offspring Health,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学生殖医学与子代健康全国重点实验室,南京211166

出　　处：《中国细胞生物学学报》2024年第4期580-595,共16页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:32270897、32070831)资助的课题。

摘　　要：精原干细胞(spermatogonial stem cells,SSCs)是体内一类特殊的成体干细胞,它的自我更新和分化平衡决定着雄(男)性持续一生的精子发生过程,是遗传信息在物种间世代稳定传递的基础。半个世纪以来,对SSCs的识别、培养、移植和命运调控相关分子机制的研究极大拓展了人们对其生物学特性的认知。该综述将介绍SSCs研究的相关历史、重要里程、进展和依然面临的瓶颈问题,以期为生育力拯救、干细胞基因改造、濒危动物多样性保护、畜牧业生产等研究和应用提供参考。SSCs(spermatogonial stem cells)are the unique adult stem cells because the balance between their self-renewal and differentiation determines lifelong spermatogenesis in the body,which also supports the transmission of genetic information from generation to generation in species.Over the past half century,the development of cell identification,culture,allogeneic transplantation and the study of fate regulation on SSCs have greatly improved our understanding of their biological properties.This review introduces the history,milestones,recent progress and unresolved issues still faced of SSC studies,and aims to summarize the current knowledge with a view to providing reference for fertility preservation,stem cell genetic modification,endangered species conservation,and livestock production.

关 键 词：精原干细胞 命运决定 男性生育力 RNA结合蛋白 表观调控 

分 类 号：Q344[生物学—遗传学]