母源肥胖与生殖健康的研究进展  

Research Advances of Maternal Obesity and Reproductive Health

作　　者：何钰 唐守彬 韩龙森 王强[1] HE Yu;TANG Shoubin;HAN Longsen;WANG Qiang(State Key Laboratory of Reproductive Medicine and Offspring Health,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学生殖医学与子代健康全国重点实验室,南京211166

出　　处：《中国细胞生物学学报》2024年第4期604-611,共8页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81925014)资助的课题。

摘　　要：随着肥胖的流行,育龄期女性中肥胖患者比例持续上升,对女性生殖健康产生严重影响。其中,卵母细胞及胚胎质量、胎儿及子代生长发育状况一直备受关注。该文将从卵母细胞质量、胚胎和胎儿生长发育以及后代健康三个方面阐述母源肥胖对生殖健康的影响,并结合已报道的机制提出潜在的干预靶标,以期改善肥胖引起的生殖细胞质量低下,避免遗传性疾病发生、促进优生优育。With an escalating global epidemic of obesity,the prevalence of obesity among reproductive women continues to rise,adversely impacting female reproductive health.It has been widely reported that maternal obesity has profound effects on oocyte and embryo qualities,as well as fetal and offspring development.This article aims to elucidate the influence of maternal obesity on reproductive health from three aspects:oocyte quality,embryo and fetal development,offspring health,and proposes potential interventions by integrating reported mechanisms to improve poor reproductive performances and offspring disease caused by maternal obesity,and consequently promoting eugenics.

关 键 词：生殖健康 母源肥胖 卵子发育 子代健康 

分 类 号：R169[医药卫生—公共卫生与预防医学] R589.2