DNA损伤修复与卵巢衰老研究进展  

Advances in DNA Damage Repair and Ovarian Aging

作　　者：赵思敏 赵世斗 秦莹莹 ZHAO Simin;ZHAO Shidou;QIN Yingying(State Key Laboratory of Reproductive Medicine and Offspring Health,Center for Reproductive Medicine,Institute of Women,Children and Reproductive Health,Shandong University,National Research Center for Assisted Reproductive Technology and Reproductive Genetics,Shandong University,Key Laboratory of Reproductive Endocrinology(Shandong University),Ministry of Education,Shandong Technology Innovation Center for Reproductive Health,Shandong Provincial Clinical Research Center for Reproductive Health,Shandong Key Laboratory of Reproductive Medicine,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Research Unit of Gametogenesis and Health of ART-Offspring,Chinese Academy of Medical Sciences(No.2021RU001),Jinan 250012,China)

机构地区：[1]山东大学生殖医学与子代健康全国重点实验室,山东大学妇儿与生殖健康研究院/山东大学附属生殖医院,山东大学国家辅助生殖与优生工程技术研究中心,山东大学生殖内分泌教育部重点实验室,山东省生殖健康技术创新中心,山东省生殖健康临床医学研究中心,山东省生殖医学重点实验室,中国医学科学院配子发生与辅助生殖子代健康研究创新单元(2021RU001),济南250012

出　　处：《中国细胞生物学学报》2024年第4期668-681,共14页Chinese Journal of Cell Biology

基　　金：国家重点研发计划(批准号:2022YFC2703800);国家自然科学基金(批准号:82125014、32170867、32370906);山东省自然科学基金重大基础研究项目(批准号:ZR2021ZD33);山东省泰山学者青年专家项目(批准号:tsqn202211370)资助的课题。

摘　　要：女性随着年龄增加生育力逐渐下降,卵巢衰老是女性生育力下降的关键原因。女性一般在35岁左右开始出现卵巢衰老,表现为卵母细胞数量减少和质量下降,共同导致生育力降低或不孕不育。遗传因素在卵巢衰老发生过程中发挥重要作用。随着高通量测序技术的发展,DNA损伤修复通路在卵巢储备建立和耗竭中的重要作用逐渐被揭示。该文就DNA损伤修复与卵巢衰老的研究进展进行了综述,包括DNA损伤修复基因在原始生殖细胞发育、卵母细胞减数分裂和卵泡维持及发育等多个过程中的作用及其机制,以及该通路基因突变与卵巢早衰的关系,并且探讨了靶向DNA损伤修复通路延缓卵巢衰老的干预策略,希望为女性生育力保护提供新的途径。Female fertility gradually decreases with age,and ovarian aging is one key reason for female sub-fertility.Women generally begin to experience ovarian aging around the age of 35 years,which is manifested as decline in both the number and quality of oocytes,leading to female sub-fertility or infertility.Genetic factors play an important role in ovarian aging.With the development of high throughput sequencing technology,the important role of DNA repair pathway in the establishment and depletion of ovarian reserve has been revealed.This article reviews the progress of DNA damage repair and ovarian aging,including the role of DNA damage repair genes in primordial germ cell development,oocyte meiosis and follicle maintenance and development,and their mutations in premature ovarian failure.In addition,this review discusses the related research on targeting DNA damage repair pathway to delay ovarian aging,hoping to provide new insights for female fertility protection.

关 键 词：DNA损伤修复 卵巢衰老 原始生殖细胞 卵母细胞 减数分裂 女性生育力保护 

分 类 号：R711.75[医药卫生—妇产科学]