子宫内膜与辅助生殖技术——从基础研究到临床转化  

Endometrium and Assisted Reproductive Rechnology—from Basic Research to Clinical Translation

作　　者：李凤 张园[2] 王琳[2] 刁飞扬[1,2] LI Feng;ZHANG Yuan;WANG Lin;DIAO Feiyang(State Key Laboratory of Reproductive Medicine and Offspring Health,Nanjing Medical University,Nanjing 211166,China;Clinical Center of Reproductive Medicine,the First Affiliated Hospital with Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学生殖医学与子代健康全国重点实验室,南京211166 [2]南京医科大学第一附属医院生殖医学中心,南京210029

出　　处：《中国细胞生物学学报》2024年第4期711-723,共13页Chinese Journal of Cell Biology

基　　金：国家重点研发计划(批准号:2022YFC2702505、2021YFC2700605)资助的课题。

摘　　要：经过四十多年的发展,辅助生殖技术已成为不孕不育的有效治疗手段。子宫内膜作为“土壤”,其正常的结构和功能是胚胎成功植入、健康发育的关键因素。子宫内膜容受性成为近年来生殖医学领域的研究热点,基础研究相应地极大促进了临床诊断流程和治疗路径的迭代。该文从子宫内膜在周期性修复、微生态平衡和胚胎着床中的生理功能出发,聚焦损伤、感染、非生理水平激素影响辅助生殖妊娠结局的病理因素及其相应诊疗措施,关注与子宫内膜相关的辅助生殖后妊娠期并发症和子代健康,从子宫内膜的基础研究到临床转化的角度,探讨进一步提高辅助生殖技术有效性和安全性的新角度和新方法。ART(assisted reproductive technology)has evolved significantly over the past four decades,establishing itself as a potent solution for infertility.The endometrium,often referred as the‘soil’,is instrumental in ensuring successful embryo implantation and healthy development.Recent years have seen a surge in research interest towards endometrial receptivity within the sphere of reproductive medicine.This interest,coupled with relevant basic research,has substantially advanced the evolution of clinical diagnostic procedures and treatment pathways.This paper delves into the physiological roles of the endometrium in cyclic repair,microbiota equilibrium,and embryo implantation.It underscores pathological factors,including injury,endometrial dysbiosis,and nonphysiological hormonal levels,that potentially influence the outcomes of ART pregnancies,and discusses the associated diagnostic and therapeutic measures.The paper also sheds light on post-ART complications and offspring health related to the endometrium.By bridging the gap between basic endometrial research and clinical application,this paper aims to explore innovative perspectives and methodologies to further enhance the efficacy and safety of assisted reproductive technology.

关 键 词：辅助生殖技术 子宫内膜损伤 子宫内膜生态失调 子宫内膜容受性 妊娠期并发症 围产期结局 

分 类 号：R714.8[医药卫生—妇产科学]