环境化学物对精母细胞的损伤及其分子机制研究进展  

Research Progress on the Damage of Spermatocytes Induced by Environmental Chemicals and Related Molecular Mechanisms

作　　者：徐抒语 陈柯佳 何悦文 彭梦凡 杨柳 王守林[1,2] XU Shuyu;CHEN Kejia;HE Yuewen;PENG Mengfan;YANG Liu;WANG Shoulin(State Key Laboratory of Reproductive Medicine and Offspring Health,Nanjing Medical University,Nanjing 211166,China;School of Public Health,Centre for Global Health,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学生殖医学与子代健康全国重点实验室,南京211166 [2]南京医科大学公共卫生学院/全球健康中心,南京211166

出　　处：《中国细胞生物学学报》2024年第4期735-747,共13页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81973091、82173562、91743205)资助的课题。

摘　　要：研究表明,许多环境化学物可影响男性精子质量和生殖能力。精母细胞是男性生殖系统中的重要组成细胞,承担着减数分裂等重要任务,具有高度复杂的基因调控网络及表观遗传修饰稳态,可能是环境化学物影响精子质量重要的作用靶点。环境化学物不仅可干扰基因调控网络使精母细胞损伤或减数分裂异常,还可能影响精子中重要蛋白的形成,导致精子质量下降。该文聚焦环境化学物损伤精母细胞及其分子机制的国内外进展,以期为探明精子异常及男性不育的分子机制、降低环境化学物的生殖危害、促进男性生殖健康提供线索。Studies report that many environmental chemicals can affect male sperm quality and reproductive ability.Spermatocytes are the important components of the male reproductive system,responsible for important tasks such as meiosis.Spermatocytes have a highly complex gene regulatory network and epigenetic modification homeostasis,which may be the important targets for environmental chemicals affecting spermatocytes and sperm quality.Environmental chemicals can not only interfere with the gene regulatory network,causing damage or abnormal meiosis in spermatocytes,but also may affect the formation of important proteins in sperm,leading to a decrease in sperm quality.This review focuses on the domestic and international progress of the environmental chemicals damaging spermatocytes and their molecular mechanisms,in order to provide clues for exploring the molecular mechanisms of abnormal sperm quality and male infertility,reducing the reproductive hazards of environmental chemicals,and promoting male reproductive health.

关 键 词：环境化学物 精母细胞 男性生殖 细胞损伤 调控机制 

分 类 号：R114[医药卫生—卫生毒理学]