辅助生殖技术后代远期血压变化及影响因素  

Long-Term Blood Pressure Changes and Influencing Factors in the Offspring of Assisted Reproductive Technology

作　　者：周晓倩 孙一飞 周炜[1] 崔琳琳[1] ZHOU Xiaoqian;SUN Yifei;ZHOU Wei;CUI Linlin(State Key Laboratory of Reproductive Medicine and Offspring Health,Institute of Women,Children and Reproductive Health,National Research Center for Assisted Reproductive Technology and Reproductive Genetics,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学生殖医学与子代健康全国重点实验室,妇儿与生殖健康研究院,国家辅助生殖与优生工程技术研究中心,济南250012

出　　处：《中国细胞生物学学报》2024年第4期838-845,共8页Chinese Journal of Cell Biology

基　　金：国家重点研发计划(批准号:2022YFC2704404);中国医学科学院医学科学创新基金(批准号:2021-I2M-5-001)资助的课题。

摘　　要：自1978年以来,辅助生殖技术(assisted reproductive technology,ART)的应用愈加广泛,其安全性也一直备受关注,人们对通过ART受孕出生的后代的健康和发育提出了担忧。目前大多数研究发现ART后代血压高于自然妊娠后代。既往文献报道ART后代血压升高可能与不良的围产期结局如早产、胎儿生长受限、胎盘功能不全的发生率增加,器官结构功能的改变以及后代表观遗传的改变有关,且ART后代青少年血压升高导致成年期心血管疾病发病风险增加。该文通过总结相关文献,从ART后代远期血压变化、影响因素及其可能的机制进行详细综述。ART(assisted reproductive technology)has become more widespread since 1978,and there has always attention about the safety of this technology,raising concerns about the health and development of children conceived through ART.Most current studies have found an increased risk of elevated blood pressure in ART offspring,which may be related to adverse perinatal outcomes such as preterm birth,fetal growth restriction,increased incidence of placental insufficiency,alterations in organ structure and function,and posterior epigenetic changes,and leads to an increased risk of cardiovascular disease in adulthood.This article summarizesthe relevant literature and reviews the long-term blood pressure changes,influencing factors and possible mechanismsof ART offspring.

关 键 词：生殖技术 辅助 儿童 血压 

分 类 号：R714.8[医药卫生—妇产科学]