High-Value-Added Utilization of Turpentine:Screening of Anti-Influenza Virus Agents fromβ-Pinene Derivatives  

作　　者：Yiwen Li Hongyan Si Peng Wang Hai Luo Minggui Shen Xiaoping Rao Zhanqian Song Shibin Shang Zongde Wang Shengliang Liao 

机构地区：[1]East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration,Camphor Engineering Research Center of National Forestry and Grassland Administration,College of Forestry,Jiangxi Agricultural University,Nanchang,330045,China [2]Institute of Chemical Industry of Forestry Products,China Academy of Forestry,National Engineering Laboratory for Biomass Chemical Utilization,Key and Open Laboratory of Forest Chemical Engineering,State Forestry Administration,Key Laboratory of Biomass Energy and Material,Jiangsu Province,Nanjing,210042,China [3]College of Chemical Engineering,Huaqiao University,Xiamen,361021,China

出　　处：《Journal of Renewable Materials》2024年第1期45-56,共12页可再生材料杂志（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant Number 32260370);Youth Talent Project of Major Academic and Technical Leaders Training Program of Jiangxi Province(Grant Number 20204BCJL23045);Special Research Project on Camphor Tree(KRPCT)of Jiangxi Forestry Department(Grant Number 2020CXZX07);Innovative Leading Talent Short-Term Project in Natural Science Area of Jiangxi Province(Grant Number jxsq2018102072);the Key Research and Development Program of Jiangxi Province(Grant Number 20192BBFL60014).

摘　　要：Turpentine is a renewable and resourceful forest product.The deep processing and utilization of turpentine,particularly its primary componentβ-pinene,has garnered widespread attention.This study aimed to synthesize 40 derivatives ofβ-pinene,including nopinone,3-cyanopyridines of nopinone,myrtanyl acid,myrtanyl acylthioureas,and myrtanyl amides.We assessed the antiviral activities of theseβ-pinene derivatives against influenza virus A/Puerto Rico/8/34(H1N1)using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method.Theβ-pinene derivatives were used before and after cellular infection with the influenza virus to evaluate their preventive and therapeutic effects against the H1N1 virus.The results showed that only compound 10o exhibited a preventive effect against the H1N1 virus with a half-maximal inhibitory concentration(IC50)value of 47.6μmol/L.Among the compounds,4e,4i,and 4l demonstrated therapeutic effects against cellular infection,with compound 4e displaying the most potent therapeutic effect(IC50=17.5μmol/L),comparable to the positive control ribavirin.These findings indicated that certainβ-pinene derivatives exhibited in vitro antiviral activity against the H1N1 influenza A virus,warranting further investigation as potential anti-influenza agents.

关 键 词：Antiviral activity Β-PINENE DERIVATIVE 3-CYANOPYRIDINE influenza virus 

分 类 号：O62[理学—有机化学]