Genetic Polymorphism of 38 Y-chromosome Short Tandem Repeats in Beijing Han Population from China  

作　　者：Yan Liu Chengtao Jiang Dong Zhao Jinpei Zhang Libin Wu Di Lu Li Yuan 

机构地区：[1]Shanghai Key Lab of Forensic Medicine,Key Lab of Forensic Science,Ministry of Justice,Academy of Forensic Science,Shanghai,China [2]Key Laboratory of Evidence Science of Ministry of Education,China University of Political Science and Law,Beijing,China [3]Beijing Tianping Judicial Expert Center,Beijing,China

出　　处：《Journal of Forensic Science and Medicine》2023年第4期340-346,共7页法庭科学与法医学杂志（英文）

基　　金：supported by opening research grants from Shanghai Key Lab of Forensic Medicine,Key Lab of Forensic Science,Ministry of Justice,PR.China(Academy of Forensic Science)(No.KF202111);supported by the Fundamental Research Funds for the Central Universities.

摘　　要：Objective:To investigate 38 Y-chromosome short tandem repeat(Y-STR)genetic polymorphisms in Beijing Han and analyze the genetic distance with neighboring or linguistically similar populations.Materials and Methods:In the study,we selected 531 unrelated male individuals of Beijing Han,and the results were statistically analyzed by testing with GSTAR™41Y reagents.Results:The allele peak heights were balanced among the Y loci,the amplified fragment ranged from 100 to 500 bps.A total of 531 haplotypes were detected in 531 samples.Eight null genotypes were observed on locus DYS448.One and three double alleles were observed on single-copy locus DYS576 and DYS19,respectively.DYS385 a/b,DYF387S1 a/b,and DYS527 a/b were more common in double copies,but 3,13,and 11 triple alleles were detected,respectively.The gene diversity values of Y-STRs except DYS391,DYS438,and DYS645 were>0.5.Twenty-seven Y-STRs of Beijing Han population were selected for genetic distance comparison with 17 populations including Changchun Han,with Rst values ranging from 0.0002 to 0.1703.Conclusion:The 38 Y-STRs in this study have strong male lineage identification ability and have great potential for individual identification,kinship identification,Y-STR database construction,and genetic relationship research.

关 键 词：Genetic distance genetic polymorphism Han nationality in Beijing short tandem repeats Y-CHROMOSOME 

分 类 号：D919[医药卫生—法医学] Q3[政治法律—法学]