氮杂环卡宾-铁配合物催化碳-碳偶联反应的研究进展  

Research Progress in C—C Coupling Reactions Catalyzedby N -heterocyclic Carbene Iron Complexes

作　　者：代祯 王亚鹏 赵慧慧 张斌[1] 刘万聪 张静学 何俊 胡嘉涛 刘浩 张翔 DAI Zhen;WANG Yapeng;ZHAO Huihui;ZHANG Bin;LIU Wancong;ZHANG Jingxue;HE Jun;HU Jiatao;LIU Hao;ZHANG Xiang(School of Pharmacy(Sichuan Industrial Institute of Antibiotics),Chengdu University,Chengdu 610052,China)

机构地区：[1]成都大学药学院(四川抗菌素工业研究所),四川成都610052

出　　处：《合成化学》2024年第5期469-484,共16页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(82204220);四川省自然科学基金资助项目(2023NSFSC1689,2023NSFSC1081);校级大学生创新训练项目(CDUCX2024705)。

摘　　要：作为传统贵金属催化剂的理想替代品,铁具有来源广泛、毒性低和环境兼容性好等特点,目前被用于多种环境友好的催化过程。近年来,氮杂环卡宾(NHC)由于其独特的空间和电子性质,常作为配体,不仅能够被应用于贵金属(如钯、镍和铑等)催化,在铁催化中也得到了广泛的应用。本文综述了氮杂环卡宾及铁配合物催化剂的特点,并重点讨论了近十年其催化的碳-碳偶联包括芳基-芳基交叉偶联、芳基-烷基交叉偶联、烷基-烷基交叉偶联等反应中的研究进展。As an ideal alternative to traditional precious metal catalysts, iron has the advantages of wide sources, low toxicity, and good environmental compatibility, and is currently used in various environmentally friendly catalytic processes. In recent years, N -heterocyclic carbene (NHC) has been widely used as a ligand not only in the catalysis of precious metals (such as palladium, nickel, rhodium, etc. ) but also in iron catalysis due to its unique spatial and electronic properties. This article reviews the characteristics of NHC-Fe catalysts and focuses on the research progress in carbon-carbon coupling reactions catalyzed by NHC-Fe complexes in the past decade, including aryl-aryl cross-coupling, aryl-alkyl cross-coupling, alkyl-alkyl cross-coupling, and others.

关 键 词：氮杂环卡宾配体 铁催化剂 SUZUKI偶联反应 Kumada偶联反应 合成 催化活性 

分 类 号：O62[理学—有机化学]