(S)-普萘洛尔的合成、应用及剂型研究进展  

Research Progress of Synthesis, Applicationand Dosage Form S -propranolol

作　　者：乔丽欣 边保吉 张强[1] 何炜 QIAO Lixin;BIAN Baoji;ZHANG Qiang;HE Wei(College of Chemistry and Environmental Sciences,Shaanxi University of Technology,Hanzhong 723001,China;Department of pharmacy,Air Force Medical University,Xi′an 710032,China)

机构地区：[1]陕西理工大学化学与环境科学学院,陕西汉中723001 [2]空军军医大学药学系,陕西西安710032

出　　处：《合成化学》2024年第5期485-500,共16页Chinese Journal of Synthetic Chemistry

基　　金：秦创原队伍建设项目(2022KXJ-101);两链融合项目(S2022-YF-LLRH-12-0002);国家自然科学基金面上项目(21272272)。

摘　　要：(S)-普萘洛尔是一种重要的β受体阻滞剂,用于治疗心血管疾病、焦虑症、甲状腺功能亢进等多种疾病。本文综述了迄今为止用于制备(S)-普萘洛尔的化学合成方法,如不对称拆分法、手性源合成法和不对称催化法。讨论了(S)-普萘洛尔口服和外用等多种新剂型,以及(S)-普萘洛尔在心血管疾病、焦虑症、甲状腺功能亢进、特发性震颤等疾病上的应用。本文期望为(S)-普萘洛尔的合成方法、应用和剂型研究提供参考。( S )-Propranolol is a crucial β -blocker utilized in the treatment of cardiovascular diseases, anxiety disorders, hyperthyroidism, and various other medical conditions. This review provides an overview of the chemical synthesis techniques utilized thus far for the production of ( S )-propranolol, including asymmetric resolution, chiral source synthesis and asymmetric catalysis. Besides, a variety of new dosage forms of ( S )-propranolol, such as oral and external use, and the application of ( S )-propranolol in cardiovascular diseases, anxiety disorders, hyperthyroidism, idiopathic tremor and other diseases were discussed. This review is anticipated to serve as a valuable resource for future investigations into the synthesis method, application and dosage form research of ( S )-propranolol.

关 键 词：(S)-普萘洛尔 Β受体阻滞剂 不对称拆分 手性源合成 不对称催化 

分 类 号：O621.3[理学—有机化学]