滋阴疏肝颗粒配合耳穴贴压法治疗女童性早熟的疗效及对其性激素、性腺体积的影响  

Efficacy of Ziyin Shugan Granule Combined with Auricular-Plaster Therapy for Girls with Precocious Puberty and Its Influence on Sex Hormones and Gonad Volume

作　　者：马玲[1] 钟利国[1] 杨亚梦 MA Ling;ZHONG Li-guo;YANG Ya-meng(Department of Traditional Chinese Medicine,The First People′s Hospital of Jingzhou/The First Affiliated Hospital of Yangtze University,Jingzhou Hubei 434000;Department of Rheumatology,The First People′s Hospital of Jingzhou/The First Affiliated Hospital of Yangtze University,Jingzhou Hubei 434000)

机构地区：[1]荆州市第一人民医院/长江大学附属第一医院中医科,湖北荆州434000 [2]荆州市第一人民医院/长江大学附属第一医院风湿免疫科,湖北荆州434000

出　　处：《世界中西医结合杂志》2024年第4期705-710,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：荆州市2022年度医疗卫生科技项目(2022HC06)。

摘　　要：目的 观察滋阴疏肝颗粒配合耳穴贴压法治疗女童性早熟的疗效及对其性激素、性腺体积的影响。方法 选取2021年1月—2022年10月期间荆州市第一人民医院收治的性早熟女童98例,按随机数字表法分为对照组和观察组,每组各49例。对照组患儿给予亮丙瑞林治疗,观察组给予滋阴疏肝颗粒配合耳穴贴压法治疗,疗程3个月。观察比较两组患儿临床疗效、不良反应情况,治疗前后中医证候积分,性激素[血清孕酮(Progesterone,P)、睾酮(Testosterone,T)、雌二醇(Estradiol,E_(2))、黄体生成素(Luteinizing hormone,LH)、促卵泡激素(Follicle-stimulating hormone,FSH)和催乳素(Prolactin,PRL)]、乳核指数、子宫体积、卵巢体积和骨龄(Bone age,BA)/生活年龄(Chronological age,CA)比值。结果 治疗后两组患儿中医证候积分较治疗前降低,差异有统计学意义(P<0.05);且观察组中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿血清性激素P、LH、FSH、E_(2)和PRL水平均较治疗前降低,差异有统计学意义(P<0.05),T水平与治疗前比较,差异无统计学意义(P>0.05);且观察组血清性激素P、LH、FSH、E_(2)和PRL水平均明显低于对照组,差异有统计学意义(P<0.05),T水平与对照组比较,差异无统计学意义(P>0.05)。治疗后两组患儿子宫体积、卵巢体积、乳核指数及BA/CA值均较治疗前降低,差异有统计学意义(P<0.05);且观察组子宫体积、卵巢体积、乳核指数及BA/CA值均明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组的临床总有效率87.50%(42/48)明显高于对照组72.34%(34/47),差异有统计学意义(χ^(2)=6.247,P=0.012)。治疗期间,两组患儿不良反应发生率比较,差异无统计学意义(χ^(2)=0.146,P=0.702)。结论 滋阴疏肝颗粒配合耳穴贴压法治疗女童性早熟可调节性激素水平,缩小性腺体积,抑制第二性征提前发育,提高临床疗效。Objective To observe the effect of Ziyin Shugan Granule combined with auricular-plaster therapy on girls with precocious puberty and its influence on sex hormones and gonad volume.Methods A total of 98 girls with precocious puberty admitted to the First People′s Hospital of Jingzhou from January 2021 to October 2022 were selected and divided into a control group and an observation group by random number table,with 49 in each group.The girls in the control group were treated with leuprorelin,while those in the observation group received Ziyin Shugan Granule combined with auricular-plaster therapy for 3 months.The clinical efficacy,adverse reactions and traditional Chinese medicine(TCM)syndrome scores before and after treatment were compared between the groups.Sex hormones[serum progesterone(P),testosterone(T),estradiol(E_2),luteinizing hormone(LH),follicle-stimulating hormone(FSH),and prolactin(PRL)],breast nucleus index,uterine volume,ovarian volume,and bone age(BA)/chronological age(CA)ratio were also measured and compared between the two groups.Results After treatment,TCM syndrome scores for the two groups of children decreased compared with the conditions before treatment(P<0.05),and the observation group had lower scores than the control group(P<0.05).Serum levels of P,LH,FSH,E_2,and PRL were down-regulated after treatment compared with those before treatment(P<0.05),and the observation group exhibited lower levels compared with the control group(P<0.05).Changes in serum T level were not significant(P>0.05),and there was no difference between the two groups after treatment(P>0.05).Uterine volume,ovarian volume,breast nucleus index,and BA/CA ratio decreased in both groups compared with the conditions before treatment(P<0.05),with the observation group having greater reductions than the control group(P<0.05).The total clinical effective rate was 87.50%(42/48)in the observation group,higher than the 72.34%(34/47)in the control group(χ^(2)=6.247,P=0.012).No difference was observed in the incidence of adverse r

关 键 词：性早熟 女童 滋阴疏肝颗粒 耳穴贴压 

分 类 号：R586.23[医药卫生—内分泌]