滋水清肝饮联合脑活素治疗后循环缺血性眩晕患者的临床疗效及对其脑神经递质的影响  

Clinical Efficacy of Zishuiqinggan Decoction Combined with Cerebrolysin in the Treatment of Patients with Posterior Circulation Ischemic Vertigo and Its Influence on Brain Neurotransmitters

作　　者：李帆 周丽娟 张志军 LI Fan;ZHOU Li-juan;ZHANG Zhi-jun(Department of Chinese Medicine,People′s hospital of Henan University of Chinese Medicine,Zhengzhou Henan 450000;Department of Dermatology,Zhengzhou Central Hospital Affiliated of Zhengzhou University,Zhengzhou Henan 450000)

机构地区：[1]河南省中医药大学人民医院中医科,河南郑州450000 [2]郑州大学附属郑州中心医院皮肤科,河南郑州450007

出　　处：《世界中西医结合杂志》2024年第4期755-758,763,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河南省中医药科学研究专项课题(2021JDZY069)。

摘　　要：目的 探讨滋水清肝饮联合脑活素治疗后循环缺血性眩晕的疗效及对脑神经递质的影响。方法 选取2019年1月—2022年1月期间河南省中医药大学人民医院收治的后循环缺血性眩晕患者100例作为研究对象,按照随机抽签法分为对照组和观察组,每组各50例。对照组给予脑活素治疗,观察组在对照组基础上加用滋水清肝饮治疗,疗程均为2周。记录两组患者治疗前后中医证候积分、基底动脉和椎动脉血流速度及脑神经递质(5-羟色胺、多巴胺)含量的变化,并对两组患者进行疗效及安全性评价。结果 治疗后观察组临床总有效率92.00%(46/50)高于对照组74.00%(37/50),差异有统计学意义(P<0.05)。治疗后两组患者中医证候积分均较治疗前降低,差异有统计学意义(P<0.05);且观察组中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者基底动脉、椎动脉血流速度均较治疗前升高,差异有统计学意义(P<0.05);且观察组基底动脉、椎动脉血流速度均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清多巴胺、5-羟色胺水平均较治疗前升高,差异有统计学意义(P<0.05);且观察组血清多巴胺、5-羟色胺水平均明显高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者均无出现严重不良反应,肝肾功能及血尿常规检查无明显异常。结论 后循环缺血性眩晕患者经滋水清肝饮联合脑活素治疗,其临床症状明显改善,脑部血流速度加快,神经递质含量增加,疗效显著,且具有良好的安全性。Objective To explore the curative effect of Zishuiqinggan Decoction combined with cerebrolysin on posterior circulation ischemic vertigo and its influence on brain neurotransmitters.Methods A total of 100 patients with posterior circulation ischemic vertigo admitted to the People′s Hospital of Henan University of Traditional Chinese Medicine from January 2019 to January 2022 were selected as the research subjects.They were randomly divided into a control group and an observation group,with 50 cases in each group.The control group was treated with cerebrolysin,while the observation group was treated with Zishuiqinggan Decoction in addition to cerebrolysin.The treatment course for both groups was 2 weeks.The changes in traditional Chinese medicine(TCM)syndrome score,basal and vertebral artery blood flow velocity,and brain neurotransmitter(5-hydroxytryptamine,dopamine)levels were recorded before and after treatment for both groups of patients Additionally,efficacy and safety evaluations were conducted for both groups of patients.Results The total clinical effective rate of the observation group after treatment was 92.00%(46/50),which was higher than that of the control group at 74.00%(37/50),with a statistically significant difference(P<0.05).After treatment,both groups of patients showed a decrease in the TCM syndrome scores compared to before treatment,with statistically significant differences(P<0.05).After treatment,both groups of patients exhibited increased blood flow velocities in the basal artery and vertebral artery compared to before treatment,with statistically significant differences(P<0.05);additionally,the blood flow velocities in the observation group were significantly higher than those in the control group,with statistically significant differences(P<0.05).Following treatment,the serum levels of dopamine and 5-hydroxytryptamine in both groups of patients increased compared to before treatment,with statistically significant differences(P<0.05);moreover,the serum levels of dopamine and 5-hydroxytryp

关 键 词：滋水清肝饮 脑活素 后循环缺血性眩晕 脑神经递质 

分 类 号：R441.2[医药卫生—诊断学]