中医药治疗新冠病毒轻型感染用药规律及疗效分析  

Analysis of Medication Rules and Clinical Efficacy in Traditional Chinese Medicine for Treatment to Mild Symptoms with COVID-19

作　　者：王誉儒 王亚勤 李英杰 王琳琳[2] 臧凝子[2] 王梅[1] 吕晓东[1] 庞立健[2] WANG Yuru;WANG Yaqin;LI Yingjie;WANG Linlin;ZANG Ningzi;WANG Mei;LYU Xiaodong;PANG Lijian(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;The First Affiliated Hospital of Liaoning University of Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中华中医药学刊》2024年第5期8-13,I0004,共7页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82274440);国家中医药管理局中医络病重点学科项目(辽财指社〔2022〕304号);辽宁省新冠肺炎疫情防控应急科研公关定向项目(辽科发〔2022〕28号);吕晓东辽宁省名中医传承工作室建设项目(辽中医药函〔2021〕1号)。

摘　　要：目的研究辽宁丹东83例新型冠状病毒轻型感染者的用药规律及疗效分析。方法收集2022年6月5日—2022年6月18日收住入丹东市第六人民医院、丹东结核病医院及职专方舱的83例新冠病毒轻型感染者。基于Excel及SPSS对资料进行频数分析、关联分析、聚类分析及回归分析。结果共收录83首处方,涉及103味中药,共1523味次。使用频次前10位的药物分别为蒲公英、柴胡、甘草、苦杏仁、桔梗、薏苡仁、黄芩、麦冬、金银花、木香。药物四气频数前3位分别为寒性、温性、平性。药物五味频数前3位分别为苦味、甘味、辛味。药物归经频数前3位分别为肺经、胃经、脾经。药物功效频数前3位分别为清热解毒、利尿通淋、利水渗湿。对处方高频中药进行关联规则分析,剔出甘草对关联药物的影响,结果显示柴胡、蒲公英、苦杏仁、桔梗之间存在显著关联。经聚类分析,得出5类药物。经回归分析,显示服药前核酸阳性天数每增加1d,服用中药后核酸阳性天数≥4d的可能性将增加37.4%。结论新型冠状病毒轻型感染的中医药治疗,应从肺、胃、脾入手,以清热解毒为主,兼以清利湿热、理气化痰、宣肺止咳、固护气阴,早期及时干预是疗效的关键。Objective To study the medication pattern and efficacy analysis of 83 patients with mild symptoms with corona vi⁃rus disease 2019(COVID-19)in Dandong,Liaoning.Methods A total of 83 patients with mild symptoms with COVID-19 ad⁃mitted to the Sixth People's Hospital of Dandong,Dandong Tuberculosis Hospital and Vocational College Square Cabin from June 5,2022 to June 18,2022 were collected.Frequency analysis,correlation analysis,cluster analysis and regression analysis were performed on the data based on Excel and SPSS.Results A total of 83 prescriptions involving 103 Chinese medicines were includ⁃ed,with a total of 1523 times.The top 10 drugs in terms of frequency of use were Pugongying(Taraxaci Herba),Chaihu(Bupleuri Radix),Gancao(Glycyrrhizae Radix Et Rhizoma),Kuxingren(Armeniacae Semen Amarum),Jiegeng(Platycodonis Radix),Yiy⁃iren(Coicis Semen),Huangqin(Scutellariae Radix),Maidong(Ophiopogonis Radix),Jinyinhua(Lonicerae Japonicae Flos)and Muxiang(Aucklandiae Radix).The top 3 frequencies of the four Qi of the drugs were cold,warm and flat.The top 3 flavors of the drugs were bitter,sweet and pungent.The top 3 frequency of meridian tropism were lung meridian,stomach meridian and spleen meridian.The top 3 frequencies of drug efficacy were clearing heat and removing toxins,relieving stranguria and promoting urination and draining dampness.The association rules were analyzed for the prescribed high-frequency Chinese medicines,and the effect of Gancao(Glycyrrhizae Radix Et Rhizoma)on the associated medicines was excluded,which showed that there were significant associations among Pugongying(Taraxaci Herba),Chaihu(Bupleuri Radix),Kuxingren(Armeniacae Semen Amarum)and Jiegeng(Platycodonis Radix).Through cluster analysis,5 types of drugs were identified.Through regression analysis,it is shown that for every additional day of nucleic acid positivity before medication,the likelihood of a nucleic acid positivity of≥4 d after taking traditional Chinese medicine will increase by 37.4%.Conclusion The TCM treatment of CO

关 键 词：新型冠状病毒感染 用药规律 关联规则 系统聚类 临床疗效 

分 类 号：R259.631[医药卫生—中西医结合] R511[医药卫生—中医内科学]