中医药调控胃干细胞对胃癌前疾病作用的研究进展  

Effects of Traditional Chinese Medicine Regulating Gastric Stem Cells on Gastric Precancerous Diseases:A Review

作　　者：王培[1] 严展鹏[2,3] 肖雄[4] 朱方石 WANG Pei;YAN Zhanpeng;XIAO Xiong;ZHU Fangshi(Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210022,Jiangsu,China;The Third Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing 210028,Jiangsu,China;Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,Jiangsu,China;The Second Affiliated Hospital,Nanjing University of Chinese Medicine,Nanjing 210017,Jiangsu,China)

机构地区：[1]南京中医药大学附属南京中医院,江苏南京210022 [2]南京中医药大学第三临床医学院,江苏南京210028 [3]江苏省中医药研究院,江苏南京210028 [4]南京中医药大学第二附属医院,江苏南京210017

出　　处：《中华中医药学刊》2024年第5期52-56,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82305156,81804071);江苏省自然科学基金项目(BK20230162);第三批江苏省老中医药专家学术经验继承工作项目(20SSC007,20SSC002)。

摘　　要：胃干细胞是存在于胃组织中的成体干细胞,具有自我更新和定向分化潜能。最新研究表明,胃干细胞的增殖和分化影响胃癌前疾病的发病、病理改变及预后。近年来,中医药对胃干细胞调控作用的研究取得了进展,文献报道显示,胃干细胞功能特征与中医理论存在一定的相关性,中医药能通过影响胃干细胞标志物表达、调控胃干细胞相关信号通路的异常以及对癌变胃干细胞增殖的影响而发挥对胃溃疡、慢性萎缩性胃炎(Chronic Atrophic Gastritis,CAG)等胃癌前疾病的生物学作用。就近10年上述内容的相关研究进展进行综述。Gastric stem cells are adult stem cells present in gastric tissue with the potential for self-renewal and directed differentiation.The latest researches show that the proliferation and differentiation of gastric stem cells affect the pathogenesis,pa⁃thology and prognosis of gastric precancerous diseases.In recent years,studies on the regulation of gastric stem cells by tradition⁃al Chinese medicine have made some progress.The reports show that there is a certain correlation between the functional charac⁃teristics of gastric stem cells and the theories of traditional Chinese medicine.In addition,traditional Chinese medicine could play an important role in treating gastric ulcer,chronic atrophic gastritis(CAG)and other precancerous diseases by affecting the ex⁃pressions of gastric stem cell markers,regulating the abnormality of gastric stem cell-related signaling pathways and affecting the proliferation of cancerous gastric stem cells.In this paper,the related research progress of the above-mentioned content in the past ten years was summarized as follows.

关 键 词：胃干细胞 中医药 胃溃疡 慢性萎缩性胃炎 进展 

分 类 号：R256.3[医药卫生—中医内科学]