清瘟败毒饮颗粒结合双嘧达莫治疗儿童川崎病临床疗效及安全性观察  

Clinical Efficacy and Safety of Qingwen Baiduyin Granules(清瘟败毒饮颗粒)Combined with Dipyridamole in Treatment of Kawasaki Disease in Children

作　　者：曹小彩[1] 宋文涛[1] 胡云芝[1] 路楠楠 CAO Xiaocai;SONG Wentao;HU Yunzhi;LU Nannan(Jiaozuo People's Hospital,Jiaozuo 454000,Henan,China)

机构地区：[1]焦作市人民医院,河南焦作454000

出　　处：《中华中医药学刊》2024年第5期170-173,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省医学科技攻关计划项目(201802065)。

摘　　要：目的分析清瘟败毒饮颗粒结合双嘧达莫治疗儿童川崎病临床疗效及安全性。方法研究纳入2019年1月—2022年10月小儿内科收治的82例儿童川崎病进行分组研究,分组方法为随机数字表法,将其分为西医组和中医组,各41例,西医组给予双嘧达莫治疗,中医组治疗方法同西医组,并结合清瘟败毒饮颗粒治疗,各组数据观察:临床治疗效果、治疗前后患儿中医证候(壮热不退、肌肤斑疹、唇赤干裂、咽红目赤、关节疼痛、手足硬肿等)积分变化、患儿冠脉损伤发生率、发热持续时间、淋巴结肿大消退时间及四肢肿胀消退时间、黏膜充血消退时间、住院时间、治疗前后患儿降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)、红细胞沉降率(erythrocyte sedimentation rate,ESR)等水平炎症因子水平变化、免疫球蛋白G(immunoglobulin G,IgG)及免疫球蛋白M(immunoglobulin M,IgM)、补体C_(3)(complement 3,C_(3))等免疫指标水平变化、不良反应发生情况。结果中医组患儿治疗总有效率比西医组高,P<0.05;中医组患儿冠脉损伤发生率低于西医组,P<0.05;中医组患儿发热持续时间、淋巴结肿大消退时间及四肢肿胀消退时间、黏膜充血消退时间、住院时间均比西医组短,均P<0.05;治疗前各组患儿中医证候(壮热不退、肌肤斑疹、唇赤干裂、咽红目赤、关节疼痛、手足硬肿等)积分、PCT及CRP、ESR、IgG、IgM、C_(3)等指标比较,P>0.05,治疗后各组患儿中医证候(壮热不退、肌肤斑疹、唇赤干裂、咽红目赤、关节疼痛、手足硬肿等)积分、PCT及CRP、ESR、IgG、IgM、C_(3)等指标均改善,中医组患儿治疗后中医证候(壮热不退、肌肤斑疹、唇赤干裂、咽红目赤、关节疼痛、手足硬肿等)积分、PCT及CRP、ESR、IgG、IgM、C_(3)等指标均优于西医组,均P<0.05;中医组与西医组患儿治疗不良反应率均较低,P>0.05。结论清瘟败毒饮颗粒结合双嘧达莫Objective To analyze the clinical efficacy and safety of Qingwen Baiduyin Granules(清瘟败毒饮颗粒)combined with dipyridamole in the treatment of Kawasaki disease in children.Methods A total of 82 children with Kawasaki disease(Janu⁃ary 2019 to October 2022)admitted to the pediatric internal medicine department of the hospital were included in this study for grouping study.The grouping method was random number table method,and they were divided into Western medicine group and traditional Chinese medicine group,with 41 cases in each group.The Western medicine group was given dipyridamole treatment,and the traditional Chinese medicine group was treated with the same treatment method as the Western medicine group.Clinical treatment effect,integral changes of traditional Chinese medicine symptoms(strong heat,skin rash,red lips and dry cracks,red throat and eyes,joint pain,hand and foot swelling,etc),the incidence of coronary artery injury,the duration of fever,the regres⁃sion time of lymph node swelling and limb swelling,the regression time of mucosal congestion,the length of hospital stay,the changes of inflammatory factors such as procalcitonin(PCT),C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR),the immune indicators such as immunoglobulin G(IgG),immunoglobulin M(IgM)and complement C_(3)(C_(3))as well as the occurrence of adverse reactions were observed.Results The total effective rate of traditional Chinese medicine group was high⁃er than that of the Western group(P<0.05).The incidence of coronary artery injury in the traditional Chinese medicine group was lower than that in the Western medicine group(P<0.05).The duration of fever,the regression time of lymph node enlarge⁃ment,the regression time of limb swelling,the regression time of mucosal congestion and the length of hospital stay in traditional Chinese medicine group were shorter than those in the Western medicine group(all P<0.05).Before treatment,the scores of traditional Chinese medicine symptoms(strong heat,skin rash,red lip

关 键 词：儿童川崎病 清瘟败毒饮颗粒 双嘧达莫 治疗效果 免疫功能 不良反应 

分 类 号：R272[医药卫生—中医儿科学] R725.5[医药卫生—中医学]