糖尿病与颅内动脉支架植入术后再狭窄发生率的相关性研究  

Correlation between diabetes mellitus and restenosis incidence after intracranial arterial stenting

作　　者：步国敏 施雁[1,2] 胡丹华[2] 李睿 王芳 夏文婧[1] Bu Guomin;Shi Yan;Hu Danhua;Li Rui;Wang Fang;Xia Wenjing(Tongji University School of Medicine,Shanghai,200331;Tenth People’s Hospital of Tongji University,301 Yanchang Middle Road,Shanghai,200072)

机构地区：[1]同济大学医学院,上海200331 [2]同济大学附属第十人民医院,上海200072

出　　处：《现代科学仪器》2024年第2期117-121,共5页Modern Scientific Instruments

基　　金：国家自然基金面上项目(71774117)。

摘　　要：目的:分析糖尿病与颅内动脉支架植入术后再狭窄发生率的相关性。方法:收集我院收治的行颅内动脉支架植入术的患者193例,分析糖尿病病程、空腹血糖水平、血糖水平标准差、血糖波动等因素与颅内动脉支架术后再狭窄的相关性。结果:①高血糖组患者发生术后再狭窄发生率显著高于血糖正常组患者(P<0.05);②非再狭窄组患者的糖尿病病程、空腹血糖、糖化血红蛋白、最大血糖波动均低于再狭窄组(P<0.05)。糖尿病病程、最大血糖波动、糖化血红蛋白与颅内动脉支架植入术后支架内再狭窄独立相关。结论:糖尿病患者颅内动脉支架植入术后再狭窄的发生率更高,糖尿病病程、最大血糖波动、糖化血红蛋白可能与再狭窄的发生有关。Objective:To analyze the correlation between diabetes mellitus and restenosis after intracranial arterial stenting.Methods:193 patients who received intracranial artery stent implantation in our hospital were collected.To analyze whether the history of diabetes,course of diabetes,fasting blood glucose level,standard deviation of blood glucose level,blood glucose fluctuation and other factors were related to the occurrence of restenosis after intracranial arterial stenting.Results:The incidence of postoperative restenosis in hyperglycemia group was significantly higher than that in normal blood glucose group(P<0.05).History of diabetes,fasting blood glucose,glycosylated hemoglobin,duration of diabetes and maximum fluctuation of blood glucose in the non-restenosis group were all lower than those in the restenosis group(P<0.05);The high density lipoprotein level and medication compliance of non-restenosis group were significantly higher than those of restenosis group(P<0.05).The duration of diabetes mellitus,maximum fluctuation of blood glucose and glycosylated hemoglobin were independently correlated with intrastent restenosis after intracranial arterial stenting.Conclusion:The incidence of restenosis after intracranial arterial stenting is higher in diabetic patients.The course of diabetes,maximum fluctuation of blood sugar and glycosylated hemoglobin may be related to the occurrence of restenosis.

关 键 词：糖尿病 颅内动脉支架植入术 支架内再狭窄 

分 类 号：R587.1[医药卫生—内分泌]