奥美拉唑在分泌性中耳炎合并咽喉反流患者中的治疗价值  

Therapeutic value of omeprazole in patients with secretory otitis media combined with laryngopharyngeal reflux

作　　者：杨启梅[1] 李安 赵博 张文[1] 刘晖[1] YANG Qimei;LI An;ZHAO Bo;ZHANG Wen;LIU Hui(Department of Otolaryngology Head and Neck Surgery,Shaanxi Provincial People's Hospital,Xi'an 710068,China)

机构地区：[1]陕西省人民医院耳鼻咽喉头颈外科,陕西西安710068

出　　处：《陕西医学杂志》2024年第5期680-683,共4页Shaanxi Medical Journal

基　　金：陕西省重点研发计划项目(2023-YBSF-081);陕西省创新能力支撑计划项目(2022TD-51);陕西省人民医院科技发展孵化基金资助项目(2022YJY-20);陕西省人民医院科技人才支持计划项目(2021JY-16)。

摘　　要：目的:探讨奥美拉唑在分泌性中耳炎(SOM)合并咽喉反流(LPR)患者中的治疗价值。方法:选取单侧或双侧SOM合并LPR患者82例,根据治疗方案不同将患者分为治疗组(35例)和对照组(47例)。所有患者均给予鼓膜穿刺术、配合使用鼻部激素、口服黏液促排剂和抗组胺药物1个月。治疗组同时给予患者抗反流宣教及足疗程奥美拉唑抗反流干预。随访3个月,比较两组患者治疗前后气骨导差、七项咽鼓管功能障碍症状评分量表(ETDQ-7)评分及临床疗效。结果:两组治疗后第1~3个月气骨导差较治疗前降低(均P<0.05)。治疗组治疗后第1~3个月气骨导差低于对照组(均P<0.05)。两组患者治疗后第1~3个月ETDQ-7评分较治疗前降低(均P<0.05)。治疗组治疗后第1~3个月ETDQ-7评分较对照组降低(均P<0.05)。治疗后第2、3个月,治疗组总有效率高于对照组(均P<0.05)。结论:对于SOM合并LPR患者,奥美拉唑能改善咽鼓管功能,提高听力水平及SOM治疗效果。Objective:To investigate the therapeutic value of omeprazole in patients with secretory otitis media(SOM)combined with laryngopharyngeal reflux(LPR).Methods:A total of 82 patients with unilateral or bilateral SOM combined with LPR were selected and divided into treatment group(35 cases)and control group(47 cases)according to different treatment regiments.All patients were given tympanocentesis combined with nasal hormones,oral mucostimulants and antihistamines for one month.Patients in the treatment group were also given anti-reflux education and an adequate course of omeprazole anti-reflux intervention.The patients were followed up for 3 months,and the air bone gap,seven-item eustachian tube dysfunction questionnaire(ETDQ-7)score and clinical efficacy of the two groups were compared before and after treatment.Results:The air bone gap in 1 to 3 months after treatment was lower than that before treatment(all P<0.05).The air bone gap in the treatment group was lower than that in the control group at 1 to 3 months after treatment(all P<0.05).The ETDQ-7 scores in the first 1 to 3 months after treatment in both groups were lower than those before treatment(all P<0.05).The ETDQ-7 score of the treatment group was lower than that of the control group at 1 to 3 months after treatment(all P<0.05).At 2 and 3 months after treatment,the total effective rates of the treatment group were higher than that of the control group(all P<0.05).Conclusion:For SOM patients with LPR,omeprazole can improve the function of pharyngotympanical tube,improve the hearing level and the therapeutic effect of SOM.

关 键 词：分泌性中耳炎 咽喉反流 抗反流干预 奥美拉唑 气骨导差 七项咽鼓管功能障碍症状评分量表 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]