三氧化二砷在肿瘤治疗中临床应用及相关分子机制研究进展  

Research progress on clinical application and related molecular mechanism of arsenic trioxide in tumor treatment

作　　者：李欣 潘宇飞 万旭英 LI Xin;PAN Yufei;WAN Xuying(Department of Integrated Traditional Chinese and Western Medicine,the Third Affiliated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第三附属医院中西医结合科,上海200433 [2]海军军医大学国家肝癌科学中心,上海200433

出　　处：《陕西医学杂志》2024年第5期703-706,共4页Shaanxi Medical Journal

基　　金：国家自然科学基金资助面上项目(82373223);上海市卫生健康委员会科研项目(202340091)。

摘　　要：三氧化二砷(ATO)具有广泛抗肿瘤作用,用于治疗疾病已有2000多年的历史。自20世纪70年代以来,ATO被用于治疗急性早幼粒细胞白血病(APL)。越来越多的证据表明,ATO在其他癌种中同样发挥抗肿瘤效果,如多发性骨髓瘤、肝癌和胰腺癌等。现对ATO在肿瘤治疗中的临床应用及相关分子机制进行综述。Arsenic trioxide(ATO)has a wide range of anti-tumor effects and has been used to treat diseases for more than 2000 years.ATO has been used in the treatment of acute promyelocytic leukemia(APL)since the 1970s.Increasing evidence has shown that ATO also exerts anti-tumor effects in other cancers,such as multiple myeloma,liver cancer and pancreatic cancer.This article reviews the clinical application and related molecular mechanisms of ATO in tumor treatment.

关 键 词：三氧化二砷 肿瘤 急性早幼粒细胞白血病 临床应用 分子机制 

分 类 号：R285[医药卫生—中药学]