益气养血方联合促红素治疗糖尿病肾病腹膜透析患者肾性贫血临床观察  

Clinical efficacy of Yiqi Yangxue prescription combined with erythropoietin in the treatment of renal anemia in patients undergoing peritoneal dialysis for diabetic nephropathy

作　　者：张志辉 束永兵[1] ZHANG Zhihui;SHU Yongbing(Department 2 of Nephropathy,Lu'an Hospital of Traditional Chinese Medicine,Lu'an 237000,China)

机构地区：[1]六安市中医院肾病二科,安徽六安237000

出　　处：《陕西中医》2024年第5期630-633,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：安徽省重点研究与开发计划项目(202104J07020014)。

摘　　要：目的:探究益气养血方联合促红素治疗糖尿病肾病腹膜透析(PD)患者肾性贫血的临床疗效。方法:选择糖尿病肾病PD合并肾性贫血患者60例,按照随机数字表法分为观察组和对照组各30例,对照组应用常规促红素治疗,观察组在对照组基础上联合益气养血方治疗,评估两组疗效,比较贫血指标、腹膜功能指标水平及不良反应。结果:治疗后,观察组中医证候积分明显低于对照组,且观察组临床疗效(90.00%)明显高于对照组(66.67%)(P<0.05);治疗前两组贫血指标[血红蛋白(Hb)、血细胞比容(Hct)、红细胞计数(RBC)]比较无统计学差异(P>0.05),治疗后观察组Hb、Hct、RBC水平高于对照组(P<0.05);治疗前,两组腹膜功能指标水平[PD血尿素清除指数(Kt/V)、透析液与血液中肌酐的浓度比值(D/Pcr)、PD超滤量(UF)]比较无统计学差异(P>0.05),治疗后,观察组Kt/V、D/Pcr、UF水平高于对照组(P<0.05);观察组不良反应总发生率6.67%,对照组为23.33%,两者比较无统计学差异(P>0.05)。结论:益气养血方联合促红素治疗糖尿病肾病PD患者肾性贫血,可以有效缓解贫血症状,提高治疗疗效及改善贫血相关指标、腹膜功能,且不增加不良反应风险。Objective:To investigate the clinical efficacy of Yiqi Yangxue prescription combined with erythropoietin in the treatment of renal anemia in patients undergoing peritoneal dialysis(PD)for diabetic nephropathy.Methods:A total of 60 patients with renal anemia who underwent PD for diabetic nephropathy were selected,according to random number table method divided into observation group and control group 30 cases each.The control group was treated with routine erythropoietin,while the observation group was treated with Yiqi Yangxue prescription on the basis of the control group.Efficacy in the two groups was evaluated.Anemia indicators,peritoneal function indicators and adverse reactions were compared between the groups.Results:TCM syndrome score after treatment,the observation group was obviously lower than the control group,and the clinical curative effect(90.00%)of the observation group was obviously higher than that of control group(66.67%)(P<0.05).Two groups before treatment of anemia indicators[hemoglobin(Hb),hematocrit(Hct),RBC count(RBC)]was no difference(P>0.05),the observation group after treatment of Hb,Hct,RBC level were higher than the control group(P<0.05).Before treatment,two groups of peritoneal function index level[PD(Kt/V),blood urea clearance index of dialysate and creatinine in the blood concentration ratio(D/Pcr),PD ultrafiltration(UF)]was no difference(P>0.05),after treatment,the observation group of Kt/V,D/Pcr,UF levels higher than the control group(P<0.05).Observation group of adverse reactions to the total incidence of 6.67%,the control group was 23.33%,which showed no difference(P>0.05).Conclusion:Applying Yiqi Yangxue prescription combined with erythropoietin to treat renal anemia in patients undergoing PD for diabetic nephropathy can effectively alleviate anemia symptoms,and improve the therapeutic effect,anemia related indicators and peritoneal function,without increasing the risk of adverse reactions.

关 键 词：糖尿病肾病 益气养血方 促红素 腹膜透析 肾性贫血 

分 类 号：R587.2[医药卫生—内分泌]