磺胺嘧啶银治疗烧伤的有效性和安全性的系统评价和Meta分析  

Systematic Review and Meta-Analysis on Efficacy and Safety of Silver Sulfadiazine in the Treatment of Burn

作　　者：李文蕾 郭玉金[2] LI Wenlei;GUO Yujin(Dept.of Burn Plastic Surgery,Affiliated Hospital of Jining Medical University,Shandong Jining 272007,China;Dept.of Clinical Medicine,Jining First People’s Hospital,Shandong Jining 272002,China)

机构地区：[1]济宁医学院附属医院烧伤整形美容科,山东济宁272007 [2]济宁市第一人民医院临床药学科,山东济宁272002

出　　处：《中国医院用药评价与分析》2024年第4期469-472,477,共5页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:系统评价磺胺嘧啶银局部治疗烧伤的有效性和安全性。方法:计算机联网检索PubMed、Embase和the Cochrane Library等数据库,选取磺胺嘧啶银局部治疗烧伤的随机对照研究(干预措施为磺胺嘧啶银,对照措施为其他材料),检索时间均限定为2010年1月1日至2022年6月1日。对于纳入的随机对照研究,采用Cochrane偏倚风险评估工具评价其方法学质量,采用RevMan 5.3软件进行Meta分析,比较磺胺嘧啶银与其他材料治疗烧伤的创面愈合时间、感染率等指标。结果:最终纳入11篇文献,Meta分析结果表明,与其他材料比较,磺胺嘧啶银并不能更好地缩短烧伤的创面愈合时间,差异无统计学意义(MD=-0.31,95%CI=-2.89~2.26,P=0.81);另外,磺胺嘧啶银组患者的感染率(18.09%)与其他材料组(14.81%)比较,差异无统计学意义(P>0.05)。结论:基于目前的临床研究,与其他材料相比,磺胺嘧啶银在烧伤患者的创面愈合方面显示出更差的效果;在预防感染方面,磺胺嘧啶银与其他材料之间没有观察到差异。OBJECTIVE:To systematically review the efficacy and safety of silver sulfadiazine ointment in local treatment of burn.METHODS:PubMed,Embase,the Cochrane Library and other databases were retrieved to collect the randomized controlled study with silver sulfadiazine ointment in local treatment of burn(intervention with silver sulfadiazine and control with other materials).The retrieval time was from Jan.1st,2010 to Jun.1st,2022.For the included randomized controlled studies,Cochrane bias risk assessment tool was used to evaluate study quality,and RevMan 5.3 software was used for Meta-analysis to compare the wound healing time and infection rate of burn treated by silver sulfadiazine and other materials.RESULTS:Totally 11 studies were included.Meta-analysis results showed that compared with other materials,silver sulfadiazine could not shorten the wound healing time of burn,and the difference was not statistically significant(MD=-0.31,95%CI=-2.89-2.26,P=0.81).Meanwhile,there was no significant difference in the infection rate between silver sulfadiazine group and other materials group(18.09%vs.14.81%,P>0.05).CONCLUSIONS:Based on current clinical studies,silver sulfadiazine has shown worse effect on wound healing in burn than other materials.No differences are observed between silver sulfadiazine and other materials in the prevention of infection.

关 键 词：磺胺嘧啶银 烧伤感染 META分析 

分 类 号：R978.1[医药卫生—药品]