二代冷冻球囊治疗心房颤动合并高血压的安全性和有效性研究  

Efficacy and safety of cryoballoon ablation in patients with atrial fibrillation and hypertension

作　　者：吴梅琼[1] 林亚洲 陈林[1] 彭一鸣 张建成[1] 杨志平 陈建泉[1] 连亮华[1] WU Meiqiong;LIN Yazhou;CHEN Lin;PENG Yiming;ZHANG J iancheng;YANG Zhiping;CHEN J ianquan;LIAN Lianghua(Cardiowascular De partment,The Provincial Clinical Hospital of Fujian Medical University,Fujian Provincial Hos pital,Fuzhou,Fujian 350001,China)

机构地区：[1]福建医科大学省立临床医学院福建省立医院心内科,福州350001

出　　处：《福建医药杂志》2024年第2期31-35,共5页Fujian Medical Journal

基　　金：福建省科技厅引导性项目(2020Y0062)。

摘　　要：目的本研究旨在回顾性分析二代冷冻球囊导管治疗心房颤动合并高血压的有效性和安全性。方法选择在福建省立医院接受二代球囊冷冻消融手术的1027例房颤患者,回顾性分析两组基线资料、术中参数及并发症发生情况。利用Kaplan-Meier法计算术后12个月、24个月及36个月两组房颤患者无房扑/房颤发生的概率。结果高血压组与非高血压组在合并糖尿病、冠心病、BMI、年龄、左房大小、CHA2DS2-VASC评分、HAS-BLED评分差异有统计学意义(P>0.05);两组术中参数差异无统计学意义;围手术期主要并发症相似(3.3%vs.3.0%,P=1),两组术后12个月、24个月及36个月的成功率分别为:82.0%vs.81.2%;74.9%vs.72.9%;66.3%vs.72.9%。生存曲线差异无统计学意义(95%CI:0.75,1.4,P=0.23)。结论二代冷冻球囊肺静脉电隔离PVI治疗房颤合并高血压与治疗非高血压一样,有良好的安全性和成功率。Objective To assess the safety,efficacy and clinical success of CB2-based PVI in patients with atrial fibrillation and hypertension.Methoods A total of 1027 patients were enrolled in the study from July 2016 to October 2019 in Fujian Provincial Hospital.All patients were divided into hypertension group and control group.Baseline data,perioperative parameters,perioperative complications were recorded.The 12-month,24-month,36-month freedom from AF recurrence were comparative analyzed in two groups by Kaplan-Meier.Results Baseline data in two groups were different in diabetes mellitus,coronary heart disease,atrial diameter,BMI,CHA2DS2-VASC,HAS-BLED(P>0.05).Periprocedural parameters were similar between two groups.Major periprocedural complications were comparable(3.3%vs.3.0%;P=1);The 12-month,24-month,36-month freedom from AF recurrence were(82.0%vs.81.2%;74.9%vs.72.9%;66.3%vs.72.9%),survival curves showed no statistic difference follow-up(95%CI:0.75,1.4;P=0.23).Conclusion The safety and success rate of second-generation cryoballoon pulmonary vein isolation PVI in the treatment of atrial fibrillation with hypertension are as good as those in the treatment of non-hypertension.

关 键 词：房颤 冷冻球囊 高血压 长期结果 肺静脉电隔离 

分 类 号：R544[医药卫生—心血管疾病]