慢性阻塞性肺疾病急性加重期患者血清CCR5、PAI-1水平与肺功能及病情严重程度的关系  

Relationship between serum CCR5,PAI-1 levels and lung function and severity of patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：宋文党 朱承坡[2] 张鹏 刘春 SONG Wendang;ZHU Chengpo;ZHANG Peng;LIU Chun(Department of Outpatient,General Hospital of Tibet Military Area Command,Lhasa,Xizang 610000,China;Physical Examination Center,General Hospital of Tibet Military Area Command,Lhasa,Xizang 610000,China;Department fo Endocrinology,General Hospital of Tibet Military Area Command,Lhasa,Xizang 610000,China;Department of Traditional Chinese Medicine,General Hospital of Tibet Military Area Command,Lhasa,Xizang 610000,China)

机构地区：[1]西藏军区总医院门诊部,西藏拉萨610000 [2]西藏军区总医院体检中心,西藏拉萨610000 [3]西藏军区总医院内分泌科,西藏拉萨610000 [4]西藏军区总医院中医科,西藏拉萨610000

出　　处：《国际检验医学杂志》2024年第10期1257-1261,共5页International Journal of Laboratory Medicine

摘　　要：目的 探究慢性阻塞性肺疾病急性加重期(AECOPD)患者血清细胞趋化因子受体5(CCR5)、纤溶酶原激活物抑制剂-1(PAI-1)水平变化与肺功能及病情严重程度之间的关系。方法 选取该院2020年1月至2022年1月急诊收治的114例AECOPD患者为AECOPD组,并选取同期稳定期慢性阻塞性肺疾病(COPD)患者114例为对照组。采用酶联免疫吸附试验(ELISA)测定CCR5、PAI-1水平;比较AECOPD组与对照组及不同病情程度AECOPD患者血清CCR5、PAI-1水平及肺功能指标;Pearson相关性分析AECOPD患者血清CCR5、PAI-1水平与肺功能指标之间的关系;Spearman相关性分析AECOPD患者血清CCR5、PAI-1水平与病情严重程度之间的关系。结果 与对照组相比,AECOPD组患者血清CCR5、PAI-1水平均显著升高,差异均有统计学意义(P<0.05),肺功能指标:第1秒用力呼气量(FEV_(1))、FEV_(1)与用力肺活量比值(FEV_(1)/FVC)、FEV_(1)占预计值百分比(FEV_(1)%pred)、最大呼气中期流量(MMEF)占预计值百分比(MMEF%pred)均显著降低,差异有统计学意义(P<0.05),且随着病情程度的增加,血清CCR5、PAI-1水平逐渐增加(P<0.05),FEV_(1)、FEV_(1)/FVC、FEV_(1)%pred、MMEF%pred水平逐渐降低(P<0.05);Pearson相关性分析结果显示,血清CCR5、PAI-1水平与FEV_(1)、FEV_(1)/FVC、FEV_(1)%pred、MMEF%pred均呈显著负相关(P<0.05);Spearman相关性分析结果显示,AECOPD患者血清CCR5、PAI-1水平与病情程度呈显著正相关(r_(1)=0.432,r_(2)=0.451,P<0.05)。结论 AECOPD患者血清CCR5、PAI-1水平显著升高,且血清CCR5、PAI-1水平与AECOPD患者肺功能及病情程度密切相关。Objective To explore the relationship between the changes of serum C-C chemokine receptor 5(CCR5)and plasminogen activator inhibitor-1(PAI-1)levels in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and the lung function and the severity of the disease.Methods A total of 114 patients with AECOPD admitted in the Department of Emergency from January 2020 to January 2022 in the hospital were selected as AECOPD group,mean while 114 patients with chronic obstructive pulmonary disease(COPD)were selected as control group.The levels of CCR5 and PAI-1 were measured by enzyme-linked immunosorbent assay(ELISA).The serum CCR5 and PAI-1 levels and pulmonary function indicators were compared between AECOPD group and control group,and in patients with different disease degrees.Pearson correlation was applied to analyze the relationship between the serum CCR5,PAI-1 levels and pulmonary function indicators in AECOPD patients.Spearman correlation was applied to analyze the relationship between the serum CCR5,PAI-1 levels and the severity of the disease in AECOPD patients.Results Compared with the control group,the serum levels of CCR5 and PAI-1 in AECOPD group were obviously higher,and the differences were statistically significant(P<0.05),and the levels of pulmonary function indexes:the first second forced expiratory volume(FEV_(1)),the ratio of FEV_(1) to forced vital capacity(FEV_(1)/FVC),the percentage of FEV_(1) to expected value(FEV_(1)%pred),and the percentage of maximum mid expiratory flow(MMEF)to expected value(MMEF%pred)all significantly decreased,and the differences were statistically significant(P<0.05).With the increase of the severity of the disease,the levels of CCR5 and PAI-1 in serum gradually increased(P<0.05),and the levels of FEV_(1),FEV_(1)/FVC,FEV_(1)%pred and MMEF%pred gradually decreased(P<0.05).Pearson correlation analysis showed that serum CCR5 and PAI-1 levels were obviously negatively correlated with FEV_(1),FEV_(1)/FVC,FEV_(1)%pred,MMEF%pred(P<0.05).Spearman correlation

关 键 词：慢阻肺急性加重期 细胞趋化因子受体5 纤溶酶原激活物抑制剂-1 肺功能 病情程度 

分 类 号：R563.9[医药卫生—呼吸系统]