新型细胞因子白细胞介素-38与小儿过敏性哮喘相关性研究  

Study on the Correlation between Novel Cytokine Interleukin-38 and Allergic Asthma in Children

作　　者：张锐 ZHANG Rui(Department of Pediatrics,Urumqi Friendship Hospital,Urumqi Xinjiang,830049,China)

机构地区：[1]乌鲁木齐市友谊医院儿科,新疆乌鲁木齐830049

出　　处：《中华养生保健》2024年第11期46-50,共5页CHINESE HEALTH CARE

摘　　要：目的探讨新型细胞因子白细胞介素-38(IL-38)与小儿过敏性哮喘的关系与意义。方法选择2018年1月—2022年12月于乌鲁木齐市友谊医院就诊的60例小儿过敏性哮喘患儿作为研究对象,包括急性发作期和慢性持续期,各30例,同时选择同期30例健康小儿作为健康对照组,收集两组诱导痰IL-38水平、呼出气一氧化氮(FeNO)水平、肺功能、儿童哮喘控制测试(C-ACT)等临床资料。结果与健康对照组和慢性持续期组比较,急性发作期组的诱导痰IL-38水平明显降低,差异有统计学意义(P<0.05)。相关性分析显示,在急性发作期组中,诱导痰IL-38水平与FeNO呈显著负相关(P<0.05),而与诱导痰嗜酸粒细胞、肺功能、C-ACT评分等指标均无相关性(P>0.05)。在慢性持续期组和健康对照组中,诱导痰IL-38水平与各指标之间均无相关性(P>0.05)。多因素Logistic回归分析结果显示,C-ACT评分是小儿过敏性哮喘急性发作的独立影响因素(OR=5.427,95%CI:4.926~6.112),而IL-38不是小儿过敏性哮喘急性发作的独立影响因素(OR=1.597,95%CI:0.758~1.761)。结论IL-38可能参与小儿过敏性哮喘过程,但不是小儿过敏性哮喘急性发作的独立影响因素。Objective To investigate the relationship and significance of interleukin-38(IL-38),a new cytokine,with allergic asthma in children.Methods Sixty paediatric allergic asthma patients who attended the paediatric department of Friendship Hospital of Urumqi from January 2018 to December 2022 were selected.At the same time,30 healthy children were selected as the healthy control group.Clinical data such as IL-38 level in induced sputum,exhaled nitric oxide(FeNO),lung function and childhood asthma control test(C-ACT)were collected.Results Compared with the healthy control group and the clinical remission group,the level of IL-38 in induced sputum of the acute attack group was significantly lower(P<0.05).Correlation analysis showed that in the acute exacerbation group,the level of IL-38 in induced sputum was negatively correlated with FeNO(P<0.05),but had no correlation with eosinophils,IgE,lung function,C-ACT score and other indicators(P>0.05).In the clinical remission group and healthy control group,there was no correlation between induced sputum IL-38 level and each index(P>0.05).Multivariate logistic regression analysis showed that the score of Children's Asthma Control Test(C-ACT)was an independent influencing factor for the acute attack of allergic asthma in children(OR=5.427,95%CI:4.926~6.112),while IL-38 was not an independent influencing factor for the acute attack of allergic asthma in children(OR=1.597,95%CI:0.758~1.761).Conclusion IL-38 may participate in the process of allergic asthma in children,but it is not an independent factor influencing the acute attack of allergic asthma in children.

关 键 词：过敏性哮喘 白细胞介素-38 小儿 

分 类 号：R725.6[医药卫生—儿科]