临床输血的新希望:基于基因编辑猪的异种输血  

New hope for clinical blood transfusion:xenotransfusion based on gene-edited pigs

作　　者：崔梦一 陈蕾佳 李渊源 王恺 陈胜峰 杨博尧 宋翔宇 贾志博 左浩辰 许文静[1] 彭江[1] CUI Mengyi;CHEN Leijia;LI Yuanyuan;WANG Kai;CHEN Shengfeng;YANG Boyao;SONG Xiangyu;JIA Zhibo;ZUO Haochen;XU Wenjing;PENG Jiang(Institute of Orthopedics,the Fourth Medical Center,Chinese PLA General Hospital,Beijing 100048,China;Chinese PLA Medical School;Pharmaceutical Sciences Research Division,Department of Pharmacy,Medical Supplies Center,Chinese PLA General Hospital;Guizhou Medical University;Hebei North University;Changzhi Medical College)

机构地区：[1]解放军总医院第四医学中心骨科医学部研究所,骨科战创伤实验室,骨科再生医学北京市重点实验室,北京100853 [2]河北北方学院 [3]中国人民解放军总医院医疗保障中心药学基础研究室 [4]解放军医学院 [5]贵州医科大学 [6]长治医学院

出　　处：《中国输血杂志》2024年第5期607-612,共6页Chinese Journal of Blood Transfusion

摘　　要：虽然基于人类血液的血库能够为人们提供及时有效的输血,但因其来源受到诸多限制,科学研究从未放弃寻找新的血液来源。随着转基因技术的应用和基因编辑猪的成功培育,将基因编辑猪血液作为临床输血的潜在来源已引起广泛关注,现已有临床前研究探索基因编辑猪红细胞输注于灵长类动物体内的可行性。本文探讨了基因编辑猪红细胞体内异种输血相关研究及未来发展方向。Although blood banks based on human blood can provide blood transfusions for the wounded timely and effectively,scientific research has never given up on finding new blood sources due to the restrictions of human blood sources.With the application of transgenic technology and the successful breeding of gene-edited pigs,gene-edited pig blood as a potential source of clinical transfusion has attracted wide attention.Now there are preclinical studies showing the feasibility of transfusing gene-edited pig red blood cells into primates.This paper discusses the related research and future development of xenogeneic transfusion of porcine red blood cells by gene editing.

关 键 词：异种输血 基因编辑猪 免疫排斥反应 猪红细胞 

分 类 号：R457.1[医药卫生—治疗学]