奥硝唑注射液联合拉氧头孢钠治疗盆腔炎的疗效及对血清炎症因子的影响  

Efficacy of Ornidazole Injection Combined with Latamoxef Sodium in the Treatment of Pelvic Inflammatory Disease and Its Effect on Serum Inflammatory Factors

作　　者：胡秀平 崔晓洁 杨芳 黄岱薇 HU Xiu-ping;CUI Xiao-jie;YANG Fang;HUANG Dai-wei(Department of Gynecology,Xiamen Fifth Hospital,Xiamen,361101,China)

机构地区：[1]厦门市第五医院妇科,厦门361101

出　　处：《神经药理学报》2024年第1期38-42,共5页Acta Neuropharmacologica

基　　金：厦门市科技计划项目(No.3502Z20227421)。

摘　　要：目的:探究奥硝唑注射液联合拉氧头孢钠治疗盆腔炎的疗效及对血清炎症因子的影响。方法:选取2020年6月~2023年5月厦门市第五医院收治97例盆腔炎患者为研究对象,随机数表法分为对照组(n=49)和观察组(n=48)。对照组予以拉氧头孢钠静脉滴注治疗,观察组予以奥硝唑+拉氧头孢钠静脉滴注治疗。比较两组临床疗效及治疗前后临床症状积分、盆腔积液、炎性包块直径及血清炎症因子[C反应蛋白(C-reactive protein,CRP)、白细胞介素-6(interleukin-6,IL-6)、降钙素原(procalcitonin,PCT)]水平。结果:观察组临床总有效率较对照组更高(93.75%vs 77.55%,P<0.05)。与对照组相比,观察组治疗后临床症状评分及血清CRP、IL-6、PCT水平均更低,盆腔积液量及炎性包块直径更小(P<0.05)。两组不良反应总发生率比较差异无统计学意义(8.33%vs 6.12%,P>0.05)。结论:联合使用奥硝唑注射液可明显提高拉氧头孢钠单用治疗盆腔炎的疗效,改善临床症状及体征,降低血清炎症因子水平。Objective:To explore the efficacy of ornidazole injection combined with latamoxef sodium in the treatment of pelvic inflammatory disease and its effect on serum inflammatory factors.Methods:A total of 97 patients with pelvic inflammatory disease admitted to Xiamen Fifth Hospital from June 2020 to May 2023 were randomly(random number table method)divided into control group(n=49)and observation group(n=48).The control group was treated with intravenous drip of latamoxef sodium,and the observation group was treated with intravenous drip of ornidazole+latamoxef sodium.The clinical efficacy,clinical symptom scores,pelvic effusion,inflammatory mass diameter and serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT)]levels before and after treatment were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group(93.75%vs 77.55%,P<0.05).Compared with the control group,the clinical symptom score and serum CRP,IL-6,PCT levels were lower in the observation group after treatment,and the pelvic effusion volume and inflammatory mass diameter were smaller(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(8.33%vs 6.12%,P>0.05).Conclusion:The combined use of ornidazole injection can significantly improve the efficacy of latamoxef sodium alone in the treatment of pelvic inflammatory disease,improve clinical symptoms and signs,and reduce the level of serum inflammatory factors.

关 键 词：奥硝唑 拉氧头孢钠 盆腔炎 炎症因子 

分 类 号：R969[医药卫生—药理学]