Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly  

作　　者：Tim Böttrich Pascal Bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh 

机构地区：[1]Department of Exercise Physiology and Sports Therapy,Institute of Sports Science,Justus-Liebig-University,Giessen 35394,Germany [2]Department of Cardiology and Angiology,Justus-Liebig-University Giessen,Giessen 35392,Germany [3]Institute for Systems Immunology,Center for Tumor und Immunology,Marburg 35032,Germany [4]TH Mittelhessen,Department of Computer Science,University of Applied Sciences Giessen,Giessen 35390,Germany [5]Department of Internal Medicine,Universities of Giessen and Marburg Lung Center(UGMLC),Member of the German Center for Lung Research(DZL),Giessen 35394,Germany [6]Excellence Cluster Cardio-Pulmonary Institute(CPI),Justus-Liebig University,Giessen 35394,Germany [7]Institute of Animal Nutrition and Nutrition Physiology,Justus-Liebig-University Giessen,Giessen 35390,Germany

出　　处：《Journal of Sport and Health Science》2024年第3期288-296,I0002,共10页运动与健康科学（英文）

基　　金：funded by the Central Hessen Research Campus,Flexi Fund,Project No.20121_1_1.

摘　　要：Background:Atherosclerosis forms the pathological basis for the development of cardiovascular disease.Since pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early interventions.There is evidence that regulatory T cells(Tregs)are involved in the development of atherosclerosis.Therefore,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated signatures.Methods:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking medication.Ultrasound of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were performed.Additionally,tests were conducted to assess blood lipids and determine glucose levels.Immunophenotyping of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow cytometry.Participants were categorized according to atherosclerotic plaque status.Linear and logistic regression models were used to analyze associations between parameters.Results:SAP was detected in a total of 29 participants.The participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and mTregs(OR=1.05(95%CI:1.021.10))as ind

关 键 词：Cardiorespiratory fitness ELDERLY Regulatory T cells Subclinical atherosclerosis 

分 类 号：R543.5[医药卫生—心血管疾病]