宏基因组二代测序技术辅助诊断中枢神经系统贝氏柯克斯体感染性血管炎1例  

Diagnosis on central nervous system Coxiella burnetii infectious vasculitis assisted by metagenomic next-generation sequencing technique:one case report

作　　者：蔡衍珊[1,2] 刘子凡[3] CAI Yan-shan;LIU Zi-fan(Department of AIDS Control and Prevention,Guangzhou Center for Disease Control and Prevention,Guangzhou 510440,China;Institute of Public Health,Guangzhou Medical University&Guangzhou Center for Disease Control and Prevention,Guangzhou 510440,China;Neurology Department,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China)

机构地区：[1]广州市疾病预防控制中心艾滋病预防控制部,广东广州510440 [2]广州市疾病预防控制中心广州医科大学公共卫生研究院,广东广州510440 [3]广州医科大学附属第三医院神经内科,广东广州510150

出　　处：《中国感染控制杂志》2024年第5期628-630,共3页Chinese Journal of Infection Control

摘　　要：Q热是由贝氏柯克斯体感染引起的人畜共患病,临床表现多样且无特异性,贝氏柯克斯体颅内感染罕见,经常被误诊和漏诊,导致部分患者预后不佳。此文报告1例宏基因组二代测序(mNGS)技术辅助诊断的中枢神经系统贝氏柯克斯体颅内感染性血管炎病例,提示mNGS技术在Q热快速诊断中起到重要作用,通过早期诊断,精准治疗,明显改善患者预后。在此基础上回顾国内外相关文献,总结贝氏柯克斯体颅内感染的临床表现和诊治经验,供国内外同行参考。Q fever is a zoonotic disease caused by Coxiella burnetii,with diverse and non-specific clinical manifestations.Intracranial infection caused by Coxiella burnetii is rare and is often misdiagnosed and underdiagnosed,leading to poor prognosis in some patients.This article reports a case of central nervous system intracranial infectious vasculitis caused by Coxiella burnetii through diagnosis assisted by metagenomic next-generation sequencing(mNGS)technique,indicating that mNGS technique plays an important role in rapid diagnosis of Q fever.After early diagnosis and precise treatment,the prognosis of patient was improved significantly.On this basis,relevant literatures at home and abroad are reviewed to summarize the clinical manifestations as well as diagnosis and treatment experience of intracranial infection caused by Coxiella burnetii,providing reference for domestic and foreign peers.

关 键 词：Q热 贝氏柯克斯体 感染性血管炎 宏基因组二代测序 mNGS 

分 类 号：R513.4[医药卫生—内科学]