肠道黏膜、肠道免疫和微生物群在肠源性白念珠菌感染中的作用  

Roles of intestinal mucosa,intestinal immunity and microbiota in enterogenic Candida albicans infection

作　　者：陈慧婷 李家生 徐志昌 秦定梅 张祎 王睿睿 CHEN Hui-ting;LI Jia-sheng;XU Zhi-chang;QIN Ding-mei;ZHANG Yi;WANG Rui-rui(Department of Molecular Pharmacology,College of Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China;Engineering Laboratory for National Health Theory and Product of Yunnan Province,Kunming 650500,China;State Key Laboratory for Conservation and Utilization of Bio-Resource in Yunnan Province,Kunming 650500,China)

机构地区：[1]云南省中医药大学中药学院分子药理教研室,云南昆明650500 [2]云南省民族特色养生理论与健康产品工程实验室,云南昆明650500 [3]省部共建生物资源保护与利用国家重点实验室,云南昆明650500

出　　处：《中国感染控制杂志》2024年第5期631-637,共7页Chinese Journal of Infection Control

基　　金：国家自然科学基金项目(82260805);云南省科技厅重点研发计划项目(202103AC100005);云南省高层次人才计划项目(YNWR-QNBJ-2018-242)。

摘　　要：肠源性白念珠菌感染是指肠道内定植的白念珠菌在一定条件下发生易位,突破肠道,造成组织感染,甚至引发侵袭性白念珠菌感染。肠道黏膜作为念珠菌第一接触位点,是抵抗白念珠菌定植或侵入的第一道防线,常通过物理屏障和激活宿主免疫抑制感染。作为另一种防御机制,肠道内微生物群则通过调节pH,分泌抗菌肽和竞争黏附点共同抵抗白念珠菌侵袭感染。本综述总结肠道黏膜、肠道免疫和微生物群这三个关键因素在肠源性白念珠菌感染中的作用,为肠道定植引发侵袭性白念珠菌病的科学研究提供新思路。Enterogenic Candida albicans(C.albicans)infection refers to the translocation of intestinal colonized C.albicans under certain conditions,breaking through the intestinal tract,causing tissue infection or even invasive C.albicans infection.As the first contact point of Candida,the intestinal mucosa is the first line defending colonization or invasion of C.albicans,often inhibiting infection by physical barrier and activating host immunity.As another defense mechanism,the intestinal microbiota jointly resists the invasive infection of C.albican through regulating pH,secreting antimicrobial peptides,and competing for adhesion points.This review summarizes the roles of three key factors,namely intestinal mucosa,intestinal immunity and microbiota,in enterogenic C.albicans infection,providing new ideas for scientific research on invasive candidiasis caused by intestinal colonization.

关 键 词：肠源性白念珠菌感染 肠道黏膜 肠道免疫 肠道微生物群 白假丝酵母菌 

分 类 号：R379.4[医药卫生—病原生物学]