急性白血病患者实验室证实的黏膜屏障损伤所致血流感染发生机制与研究进展  

Pathogenesis and research progress of mucosal barrier injury laboratory-confirmed bloodstream infection in patients with acute leukemia

作　　者：赵慧函 何雨[2] 应燕萍[3] ZHAO Hui-han;HE Yu;YING Yan-ping(Department of Hematology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Laboratory Medicine,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Nursing,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;School of Information and Management,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院血液科,广西南宁530021 [2]广西医科大学第一附属医院检验科,广西南宁530021 [3]广西医科大学第一附属医院护理部,广西南宁530021 [4]广西医科大学信息与管理学院,广西南宁530021

出　　处：《中国感染控制杂志》2024年第5期646-651,共6页Chinese Journal of Infection Control

基　　金：广西医疗卫生适宜技术开发与推广应用项目(S2023066);广西医科大学第一附属医院护理临床研究攀登计划项目(YYZS2020031);广西中青年教师基础能力提升项目(2023KY0128)。

摘　　要：白血病已成为人类健康的重要威胁,感染并发症是临床白血病顺利治疗的主要障碍。白血病本身肿瘤特点和高强度化学治疗导致肠道屏障完整性损伤,肠道菌群易位是血流感染(BSI)的重要原因。实验室证实的黏膜屏障损伤所致血流感染(MBI-LCBI)是急性白血病患者BSI的重要组成,但相关研究非常有限。本文通过文献分析,综述黏膜屏障损伤、细菌易位,以及MBI-LCBI定义、诊断、流行情况,分析肠道微生态调节黏膜屏障完整性及MBI-LCBI的作用机制,以期为化学治疗介导黏膜炎及MBI-LCBI的防治及管理提供理论基础。Leukemia has become an important threat to human health,and infection complications are the main obstacle to the clinical leukemia treatment.The intestinal barrier integrity was damaged due to the tumor characte-ristics of leukemia and high-intensity chemotherapy,intestinal bacterial translocation is an important cause for bloodstream infection.Mucosal barrier injury laboratory-confirmed bloodstream infection(MBI-LCBI)is an important component of bloodstream infection in patients with acute leukemia,but relevant research is very limited.The paper reviews the mucosal barrier injury,bacterial translocation,as well as the definition,diagnosis and prevalence of MBI-LCBI,analyzes the mechanism of intestinal microecology in regulating intestinal mucosal barrier integrity and effect of MBI-LCBI,aiming to provide theoretical basis for prevention,treatment and management of chemotherapy-induced mucositis and MBI-LCBI.

关 键 词：白血病 血流感染 肠道屏障 细菌易位 

分 类 号：R446.5[医药卫生—诊断学] R733.71[医药卫生—临床医学]