血清ANXA5、SFRP5、STAT6与支气管哮喘患儿1年内再入院的关系分析  

Analysis of the relationship between serum ANXA5,SFRP5,STAT6 and readmission within 1 year in children with bronchial asthma

作　　者：刘悦欣 张舒晨 LIU Yuexin;ZHANG Shuchen(Department of Pediatrics,Shaanxi Rehabilitation Hospital,Xi′an,Shaanxi 710065,China)

机构地区：[1]陕西省康复医院儿科,陕西西安710065

出　　处：《检验医学与临床》2024年第10期1377-1380,1386,共5页Laboratory Medicine and Clinic

基　　金：陕西省卫生健康委员会2022年度卫生健康科研项目(2021D0049)。

摘　　要：目的分析血清膜联蛋白A5(ANXA5)、分泌型卷曲相关蛋白5(SFRP5)、信号转导转录激活因子6(STAT6)与支气管哮喘患儿1年内再入院的关系。方法选取2018年1月至2022年8月该院收治的210例支气管哮喘患儿作为研究对象,根据支气管哮喘患儿1年内是否再入院分为再入院组和未再入院组,再入院组30例,未再入院组180例。比较再入院组和未再入院组首次入院时血清ANXA5、SFRP5、STAT6水平,采用多因素Logistic回归分析支气管哮喘患儿1年内再入院的影响因素。绘制受试者工作特征(ROC)曲线分析血清ANXA5、SFRP5、STAT6对支气管哮喘患儿1年内再入院的预测价值。结果再入院组血清ANXA5、SFRP5水平低于未再入院组,血清STAT6水平高于未再入院组,差异均有统计学意义(P<0.05)。血清ANXA5、SFRP5水平升高是支气管哮喘患儿1年内再入院的保护因素(OR<1,P<0.05),血清STAT6水平升高是支气管哮喘患儿1年内再入院的危险因素(OR>1,P<0.05)。血清ANXA5、SFRP5、STAT6单项预测支气管哮喘患儿1年内再入院的曲线下面积(AUC)均>0.700,且3项联合检测预测的AUC为0.856。结论血清ANXA5、SFRP5、STAT6水平与支气管哮喘患儿1年内再入院密切相关,对预测患儿1年内再入院有一定价值。Objective To analyze the relationship between serum annexin A5(ANXA5),secreted frizzled-related protein 5(SFRP5),signal transducer and activator of transcription 6(STAT6)and readmission within 1 year in children with bronchial asthma.Methods A total of 210 children with bronchial asthma who were admitted to Shaanxi Rehabilitation Hospital from January 2018 to August 2022 were selected as research objects,and divided into readmission group and non-readmission group according to whether children with bronchial asthma were readmitted within 1 year or not,there were 30 cases in readmission group and 180 cases in non-readmission group.The levels of serum ANXA5,SFRP5 and STAT6 in readmission group and non-readmission group at the first admission were compared,and the multivariate Logistic regression was used to analyze the influencing factors for the readmission of children with bronchial asthma within 1 year.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum ANXA5,SFRP5 and STAT6 for readmission in children with bronchial asthma within 1 year.Results The levels of serum ANXA5 and SFRP5 in readmission group were lower than those in non-readmission group,and the level of serum STAT6 was higher than that in non-readmission group(P<0.05).Increased serum ANXA5 and SFRP5 were protective factors for readmission in children with bronchial asthma within 1 year(OR<1,P<0.05),increased serum STAT6 was a risk factor for readmission in children with bronchial asthma within 1 year(OR>1,P<0.05).The area under the curve(AUC)of serum ANXA5,SFRP5 and STAT6 in predicting readmission in children with bronchial asthma within 1 year were greater than 0.700,and the AUC of the combined detection of the three indicators was 0.856.Conclusion The levels of serum ANXA5,SFRP5 and STAT6 relate closely to the readmission of children with bronchial asthma within 1 year,which has certain value in predicting the readmission of children within 1 year.

关 键 词：支气管哮喘 膜联蛋白A5 分泌型卷曲相关蛋白5 信号转导转录激活因子6 再入院 预测价值 

分 类 号：R725.6[医药卫生—儿科] R446.1[医药卫生—临床医学]