尿促性腺激素应用于女童性早熟诊治的研究进展  

Research progress of urinary gonadotropin in diagnosis and treatment of precocious puberty in children

作　　者：张田(综述) 万乃君(审校) ZHANG Tian;WAN Naijun(Department of Pediatrics,Beijing Jishuitan Hospital Affiliated to Capital Medical University,Beijing 100035,China)

机构地区：[1]首都医科大学附属北京积水潭医院儿科,北京100035

出　　处：《检验医学与临床》2024年第10期1497-1500,共4页Laboratory Medicine and Clinic

基　　金：吴阶平医学基金会临床科研专项资助基金项目(320.6750.2020-6-86)。

摘　　要：女童性早熟的发病率在逐年上升,影响了儿童的身高及心理健康。尿促性腺激素可反映机体某一时段内促性腺激素平均水平,目前国内外已有应用尿促性腺激素水平诊断中枢性性早熟、鉴别快速进展型青春期及应用GnRHa治疗过程中的相关研究报道,未来尿促性腺激素水平应用于儿童性早熟诊治中的价值仍值得期待,但尚需要多中心大样本的研究来确定尿促性腺激素水平的正常参考范围及诊断中枢性性早熟的阈值。The incidence rate of precocious puberty in girls is increasing year by year,which affects the height and mental health of children.Urinary gonadotropin can reflect the average level of gonadotropin in a certain period of time.At present,there have been relevant studies at home and abroad on the application of urinary gonadotropin level in the diagnosis of central precocious puberty,identification of rapidly progressing puberty and the application of GnRHa in the treatment process,and the value of urinary gonadotropin level in the diagnosis and treatment of childhood precocious puberty is worthy of expectation.However,multi-center and large sample studies are needed to determine the normal reference range of urinary gonadotropin levels and the threshold for the diagnosis of central precocious puberty.

关 键 词：尿促性腺激素 GnRH激发试验 性早熟 中枢性性早熟 快速进展型青春期 

分 类 号：R446.9[医药卫生—诊断学]