Biomimetic fibril-like injectable hydrogels for wound management  

作　　者：Bo-Han Li Jin-Gai Jiang Si-Wen Du Hui-Juan Cheng Yan-Ni Song Wei Shi Dong-Liang Yang 

机构地区：[1]Key Laboratory of Flexible Electronics and Institute of Advanced Materials,School of Physical and Mathematical Sciences,Nanjing Tech University,Nanjing 211816,China

出　　处：《Biomedical Engineering Communications》2024年第2期26-27,共2页生物医学工程通讯

摘　　要：Soft tissue repair and regeneration present a significant clinical challenge.Soft hydrogels have emerged as a promising solution for promoting stem cell differentiation and facilitating soft tissue formation[1].Various materials,including synthetic polymers like polydimethyl siloxane and natural polymers like proteins,have been be used as hydrogel matrix for hydrogel preparation[2,3].However,the limited biodegradability,inhomogeneous network structure,and inadequate mechanical properties of these hydrogels hinder their long-term application in complex environments in vivo.Inspired by the nanostructure of collagen fibrils,Li et al.developed a strategy for creating injectable nanofibrillar hydrogels by combining self-assembly and chemical crosslinking of nanoparticles[4].Moreover,injectable hydrogels offer advantages as implantable materials,including better defect filling and reduced risk of infection compared to prefabricated hydrogels[5].

关 键 词：HYDROGEL INHOMOGENEOUS CROSSLINKING 

分 类 号：O63[理学—高分子化学]