X射线CT引导的小鼠皮下肿瘤精准照射  

X-ray CT Guided Precise Irradiation of Subcutaneous Tumors in Small Animals

作　　者：吴其蔚 郑澄 陈家豪 杨益东 WU Qiwei;ZHENG Cheng;CHEN Jiahao;YANG Yidong(Department of Engineering and Applied Physics,School of Physics,University of Science and Technology of China,HeFei,10358,China)

机构地区：[1]中国科学技术大学物理学院工程与应用物理系,合肥10358

出　　处：《核电子学与探测技术》2024年第2期214-222,共9页Nuclear Electronics & Detection Technology

基　　金：中央高校基本科研业务费专项资金(WK2030000037);安徽省科技重大专项(BJ2030480006)。

摘　　要：临床前小动物放射治疗是探索放射生物学机制和开发新的癌症治疗方法的重要手段。传统的小动物放疗研究由于缺乏图像引导,剂量递送误差较大,影响治疗效果和实验效率。为了克服这一限制,本研究基于实验室自主研制的小动物精准放射治疗研究平台,针对小鼠皮下肿瘤模型开发了一种图像引导放射治疗的方法。本方法在保证肿瘤控制的同时,可以最大限度减少对健康组织的损伤,更好地满足动物皮下肿瘤照射的需求。Preclinical small animal radiotherapy research plays a crucial role in investigating radiobiological mechanisms and exploring cancer therapy strategies,contributing significantly to human cancer studies.Traditional small animal radiation studies suffer from inaccuracies in dose delivery due to the lack of image guidance,resulting in compromised treatment outcome.To overcome this limitation,this study developed an image-guided irradiation method for subcutaneous tumors in mice,based on the precise small animal radiotherapy platform developed in our laboratory.This approach ensures effective tumor control while minimizing damage to healthy tissues,offering an improved method and technology for preclinical subcutaneous tumor irradiation studies.

关 键 词：放射治疗 图像引导 动物皮下肿瘤 

分 类 号：O59[理学—应用物理]