乌司他丁联合序贯机械通气治疗急性呼吸窘迫综合征患者的效果  

Effects of Ulinastatin combined with sequential mechanical ventilation in treatment of patients with acute respiratory distress syndrome

作　　者：马兆利 曹迪莉 魏东 MA Zhaoli;CAO Dili;WEI Dong(Department of Critical Care Medicine of Shangcai County People’s Hospital,Zhumadian 463800 Henan,China)

机构地区：[1]上蔡县人民医院重症医学科,河南驻马店463800

出　　处：《中国民康医学》2024年第9期25-28,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨乌司他丁联合序贯机械通气治疗急性呼吸窘迫综合征(ARDS)患者的效果。方法:回顾性分析2021年1月至2023年4月该院收治的106例ARDS患者的临床资料,根据治疗方案不同将其分为研究组和对照组各53例。对照组采用有创-无创序贯机械通气治疗,研究组在对照组基础上联合乌司他丁治疗,比较两组治疗前后肺顺应性、血气指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))、氧合指数(OI)]水平、炎性指标[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6]水平和不良反应发生率。结果:治疗7 d后,研究组动态、静态肺顺应性均高于对照组,差异有统计学意义(P<0.05);治疗7 d后,研究组PaCO_(2)水平低于对照组,PaO_(2)、OI水平均高于对照组,差异有统计学意义(P<0.05);治疗7 d后,研究组IL-6、IL-1β、TNF-α水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:乌司他丁联合序贯机械通气治疗ARDS患者可提高肺顺应性,改善血气指标水平,降低炎性指标水平,效果优于单纯序贯机械通气治疗。Objective:To investigate effects of Ulinastatin combined with sequential mechanical ventilation in treatment of patients with acute respiratory distress syndrome(ARDS).Methods:The clinical data of 106 patients with ARDS admitted to this hospital from January 2021 to April 2023 were retrospectively analyzed.According to different treatment options,they were divided into study group and control group,53 cases in each group.The control group was treated with invasive-noninvasive sequential mechanical ventilation,while the study group was treated with Ulinastatin on the basis of that of the control group.The levels of pulmonary compliance,blood gas indexes[arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2)),oxygenation index(OI)],inflammatory indexes[tumor necrosis factor-α(TNF-α),interleukin(IL)-1β,IL-6]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:After 7 days of treatment,the dynamic and static lung compliance of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).After 7 days of treatment,the level of PaCO_(2) in the study group was lower than that in the control group,the levels of PaO_(2) and OI were higher than those in the control group,and the differences were statistically significant(P<0.05).After 7 days of treatment,the levels of IL-6,IL-1βand TNF-αin the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,within 7 days of treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ulinastatin combined with sequential mechanical ventilation in the treatment of the ARDS patients can improve the pulmonary compliance,improve the blood gas index levels,and reduce the inflammatory index levels.Moreover,it is superior to single sequential mechanical ventilation treatment.

关 键 词：乌司他丁 有创-无创序贯机械通气 急性呼吸窘迫综合征 血气指标 肺顺应性 炎性指标 不良反应 

分 类 号：R563[医药卫生—呼吸系统]