艾司洛尔联合去甲肾上腺素与液体复苏治疗脓毒性休克患者的效果  

Effects of Esmolol combined with Norepinephrine and fluid resuscitation in treatment of patients with septic shock

作　　者：周艳丽 ZHOU Yanli(Department of Internal Medicine of Xuchang Beihai Hospital,Xuchang 461000 Henan,China)

机构地区：[1]许昌北海医院内科,河南许昌461000

出　　处：《中国民康医学》2024年第9期60-62,66,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察艾司洛尔联合去甲肾上腺素与液体复苏治疗脓毒性休克患者的效果。方法:回顾性分析2020—2022年该院收治的88例脓毒性休克患者的临床资料,按照治疗方式不同将其分为研究组和对照组各44例。对照组采用去甲肾上腺素联合液体复苏治疗,研究组在对照组基础上联合艾司洛尔治疗,比较两组治疗前后血流动力学指标[平均动脉压(MAP)、心率]水平、组织氧合指标[中心静脉压(CVP)、氧合指数(PaO_(2)/FiO_(2))、血乳酸]水平、临床疗效和不良反应发生率。结果:治疗后,两组MAP水平均高于治疗前,且研究组高于对照组,两组心率水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组CVP、PaO_(2)/FiO_(2)水平均高于治疗前,且研究组高于对照组,两组血乳酸水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组治疗总有效率为95.45%(42/44),高于对照组的79.55%(35/44),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:艾司洛尔联合去甲肾上腺素与液体复苏治疗脓毒性休克患者可提高治疗总有效率,改善血流动力学指标和组织氧合指标水平,其效果优于去甲肾上腺素联合液体复苏治疗。Objective:To observe effects of Esmolol combined with Norepinephrine and fluid resuscitation in treatment of patients with septic shock.Methods:The clinical data of 88 patients with septic shock admitted to this hospital from January 2020 to December 2022 were retrospectively analyzed.According to different treatment methods,they were divided into study group and control group,44 cases in each group.The control group was treated with Norepinephrine combined with fluid resuscitation,while the study group was treated with Esmolol on the basis of that of the control group.The levels of hemodynamic indexes[mean arterial pressure(MAP),heart rate]and tissue oxygenation indexes[central venous pressure(CVP)oxygenation index(PaO_(2)/FiO_(2)),blood lactic acid],the clinical efficacy,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the MAP levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the heart rate levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of CVP and PaO_(2)/FiO_(2) index in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the levels of blood lactic acid in the two groups were lower than those before the treatment,and that in the study group were lower than that in the control group;and the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group was 95.45%(42/44),which was higher than 79.55%(35/44)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Esmolol combined with Norepinephrine and fluid resuscitat

关 键 词：艾司洛尔 去甲肾上腺素 液体复苏 脓毒性休克 血流动力学 组织氧合 不良反应 

分 类 号：R631[医药卫生—外科学]