超声引导下射频消融术与腔镜下甲状腺切除术治疗良性甲状腺结节患者的效果比较  

Comparison of effects of ultrasound-guided radiofrequency ablation and endoscopic thyroidectomy in treatment of patients with benign thyroid nodules

作　　者：张建国 王琼阳 齐二峰 ZHANG Jianguo;WANG Qiongyang;QI Erfeng(Department of Thyroid and Breast Surgery of Xiangcheng County People’s Hospital,Xuchang 461700 Henan,China)

机构地区：[1]襄城县人民医院甲乳外科,河南许昌461700

出　　处：《中国民康医学》2024年第9期142-145,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较超声引导下射频消融术与腔镜下甲状腺切除术治疗良性甲状腺结节患者的效果。方法:选取2021年5月至2022年5月该院收治的124例良性甲状腺结节患者进行前瞻性研究,采用随机数字表法将其分为观察组(n=62)和对照组(n=62)。对照组采用腔镜下甲状腺切除术治疗,观察组采用超声引导下射频消融术治疗。比较两组手术相关指标水平,手术前后炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)]水平、甲状腺功能指标[促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))]水平,并发症发生率和复发率。结果:观察组手术时间、切口长度均短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05);术后1 d,两组血清CRP、IL-6、PCT水平均高于术前,但观察组低于对照组,差异有统计学意义(P<0.05);术后1个月,两组血清TSH水平均高于术前,但观察组低于对照组,两组血清FT_(3)、FT_(4)水平均低于术前,但观察组高于对照组,差异有统计学意义(P<0.05);两组并发症发生率和复发率比较,差异均无统计学意义(P>0.05)。结论:超声引导下射频消融术治疗良性甲状腺结节患者可降低手术相关指标和炎性因子水平,改善甲状腺功能指标水平,其效果优于腔镜下甲状腺切除术治疗。Objective:To compare effects of ultrasound-guided radiofrequency ablation and endoscopic thyroidectomy in treatment of patients with benign thyroid nodules.Methods:A prospective study was conducted on 124 patients with benign thyroid nodules admitted to the hospital from May 2021 to May 2022.They were divided into observation group(n=62)and control group(n=62)by using the random number table method.The control group was treated with endoscopic thyroidectomy,while the observation group was treated with ultrasound-guided radiofrequency ablation.The levels of surgery-related indicators,inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT)]and thyroid function indicators[thyroid stimulating hormone(TSH),free triiodothyronine(FT_(3)),free thyroxine(FT_(4))]before and after the surgery,the incidence of complications,and the recurrence rate were compared between the two groups.Results:The operation time and the incision length of the observation group were shorter than those of the control group,the intraoperative blood loss was less than that of the control group,and the differences were statistically significant(P<0.05).One day after the surgery,the levels of serum CRP,IL-6 and PCT in the two groups were higher than those before the surgery,but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).One month after the surgery,the serum TSH levels of the two groups were higher than those before the surgery,but that in the observation group was lower than that in the control group;the levels of serum FT_(3) and FT_(4) in the two groups were lower than those before the surgery,but those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).However,there were no significant differences in the incidence of complications and recurrence rate between the two groups(P>0.05).Conclusions:Ultrasoundguided radiofrequency ablation in the treatment of th

关 键 词：良性甲状腺结节 超声引导下射频消融术 腔镜下甲状腺切除术 炎性因子 甲状腺功能 并发症 复发率 

分 类 号：R581[医药卫生—内分泌]