不同肺表面活性物质联合双水平气道正压通气治疗新生儿呼吸窘迫综合征的效果比较  

Comparison of effects of different pulmonary surfactants combined with bi-level positive airway pressure ventilation in treatment of neonatal respiratory distress syndrome

作　　者：张艳 谢芳 崔晓慧 ZHANG Yan;XIE Fang;CUI Xiaohui(Department of Pediatrics of General Hospital of Henan Sunho Group,Shangqiu 476600 Henan,China)

机构地区：[1]河南神火集团总医院儿科,河南商丘476600

出　　处：《中国民康医学》2024年第9期152-155,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较不同肺表面活性物质联合双水平气道正压通气(BIPAP)治疗新生儿呼吸窘迫综合征(NRDS)的效果。方法:回顾性分析2021—2022年该院收治的90例NRDS患儿的临床资料,按照治疗方法不同将其分为研究组与对照组各45例。两组均予以BIPAP治疗,在此基础上,对照组联合注射用牛肺表面活性剂治疗,研究组联合猪肺磷脂注射液治疗。比较两组临床疗效,治疗前后肺功能指标[第1秒用力呼气容积(FEV_(1))、FEV_(1)/用力肺活量(FVC)]水平、血气分析指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))]水平,临床相关指标(住院费用、住院时间、平均体质量)水平和并发症发生率。结果:研究组治疗总有效率为91.11%(41/45),高于对照组的73.33%(33/45),差异有统计学意义(P<0.05);治疗后,研究组FEV_(1)、FEV_(1)/FVC水平均高于对照组,差异有统计学意义(P<0.05);治疗后,研究组PaCO_(2)水平低于对照组,PaO_(2)水平高于对照组,差异均有统计学意义(P<0.05);研究组住院时间短于对照组,住院费用少于对照组,平均体质量水平高于对照组,差异均有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:猪肺表面活性物质联合BIPAP治疗NRDS患儿可提高治疗总有效率和肺功能指标水平,改善血气分析指标、临床相关指标水平,效果优于牛肺表面活性物质联合BIPAP治疗。Objective:To compare effects of different pulmonary surfactants combined with bi-level positive airway pressure(BIPAP)in treatment of neonatal respiratory distress syndrome(NRDS).Methods:The clinical data of 90 children with NRDS admitted to this hospital from 2021 to 2022 were retrospectively analyzed.According to different treatment methods,they were divided into study group and control group,45 cases in each group.Both groups were treated with BIPAP.On this basis,the control group was treated with Calf pulmonary surfactant for injection,while the study group was treated with Poractant alfa injection.The clinical efficacy,the levels of lung function indexes[forced expiratory volume in one second(FEV_(1)),FEV_(1)/forced vital capacity(FVC)],blood gas analysis indexes[arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2))]before and after the treatment,and the clinical related indexes(hospitalization expenses,hospitalization time,average body mass),and the incidence of complications were compared between the two groups.Results:The total effective rate of the study group was 91.11%(41/45),which was higher than 73.33%(33/45)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FEV_(1) and FEV_(1)/FVC in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of PaCO_(2) in the study group was lower than that in the control group,the level of PaO_(2) was higher than that in the control group,and the differences were statistically significant(P<0.05).The hospitalization time of the study group was shorter than that of the control group,the hospitalization expenses was less than that of the control group,the average body mass level was higher than that of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of complications between the two gro

关 键 词：猪肺磷脂注射液 牛肺表面活性剂 双水平气道正压通气 新生儿呼吸窘迫综合征 肺功能 血气分析 并发症 

分 类 号：R722.1[医药卫生—儿科]