加巴喷丁联合血液灌流治疗老年维持性血液透析合并中重度不宁腿综合征患者的疗效分析  

Efficacy of gabapentin combined with hemoperfusion in the treatment of moderate to severe restless legs syndrome in elderly patients undergoing maintenance hemodialysis

作　　者：朱虹 徐明成 闻君君 ZHU Hong;XU Ming-cheng;WEN Jun-jun(Department of Blood Purification Center,Zhanlan Road Hospital of Xicheng District,Beijing 100044,China)

机构地区：[1]北京市西城区展览路医院血液净化中心,100044

出　　处：《中国实用医药》2024年第9期6-11,共6页China Practical Medicine

摘　　要：目的观察加巴喷丁联合血液灌流治疗老年维持性血液透析合并中重度不宁腿综合征(RLS)患者的疗效。方法40例老年维持性血液透析合并中重度RLS患者,随机分为观察组和对照组,各20例。两组患者每周均行2次常规血液透析,1次血液透析联合血液灌流治疗。观察组每晚口服加巴喷丁。比较两组治疗前后国际不宁腿综合征评定量表(IRLS)评分、匹兹堡睡眠指数量表(PSQI)评分、简明健康状况调查量表(SF-36)评分及实验室检查指标[甲状旁腺激素(iPTH)、血β_(2)微球蛋白(β_(2)-MG)]水平,观察不良反应发生情况。结果对照组治疗1周后IRLS评分较本组治疗前无改善(P>0.05);对照组治疗4、8周后IRLS评分较本组治疗期前降低,差异有统计学意义(P<0.05)。观察组治疗1、4、8周后IRLS评分均较本组治疗前降低,且观察组治疗1、4、8周后IRLS评分(13.40±3.17)、(6.40±2.46)、(4.60±0.84)分低于对照组的(20.10±5.55)、(16.60±5.02)、(12.20±4.76)分,差异有统计学意义(P<0.05)。治疗后,两组PSQI评分均较本组治疗前下降,且观察组PSQI评分(5.20±1.75)分低于对照组的(7.00±1.15)分,差异有统计学意义(P<0.05)。治疗前,两组生理机能(PF)、生理职能(RP)、情感职能(RE)、社会功能(SF)、躯体疼痛(BP)、精力(VT)、精神健康(MH)和一般健康状况(GH)、健康变化(HT)评分及总分比较,差异无统计学意义(P>0.05)。治疗后,对照组RE、VT评分及总分高于本组治疗前,差异有统计学意义(P<0.05);观察组RP、RE、SF、VT、MH、GH、HT评分及总分高于本组治疗前,差异有统计学意义(P<0.05)。治疗后,观察组RE、SF、VT、MH评分及总分分别为(80.00±17.21)、(50.00±10.21)、(37.50±9.20)、(80.80±7.25)、(528.90±33.01)分,高于对照组的(60.00±21.08)、(38.75±12.43)、(29.00±7.38)、(72.20±10.17)、(437.65±36.73)分,差异有统计学意义(P<0.05)。治疗前后,两组iPTH及β_(2)-MG水平组间及组内比较差异无�Objective To observe the efficacy of gabapentin combined with hemoperfusion in the treatment of moderate to severe restless legs syndrome(RLS)in elderly patients undergoing maintenance hemodialysis.Methods 40 elderly patients with maintenance hemodialysis complicated with moderate to severe RLS were randomly divided into an observation group and a control group,with 20 cases in each group.Both groups were treated with conventional hemodialysis twice a week,and hemodialysis combined with hemoperfusion once a week.The observation group took gabapentin orally every night.The scores of International Restless Leg Syndrome Rating Scale(IRLS),Pittsburgh Sleep Quality Index(PSQI),36-Item Short-Form Health Survey(SF-36)and laboratory examination indicators[intact parathyroidism hormone(iPTH)andβ_(2)-microglobulin(β_(2)-MG)]before and after treatment.Results IRLS score of the control group was not improved after 1 week of treatment compared with that before treatment in this group(P>0.05).IRLS scores in the control group after 4 and 8 weeks of treatment were lower than those before treatment in this group,and the difference was statistically significant(P<0.05).After 1,4 and 8 weeks of treatment,IRLS scores in the observation group were lower than those before treatment in this group;IRLS scores in the observation group were(13.40±3.17),(6.40±2.46)and(4.60±0.84)points,which were lower than(20.10±5.55),(16.60±5.02)and(12.20±4.76)points in the control group;the difference was statistically significant(P<0.05).After treatment,PSQI scores in both groups decreased compared with those before treatment in this group,and the observation group had lower PSQI score of(5.20±1.75)points than(7.00±1.15)points in the control group.The difference was statistically significant(P<0.05).Before treatment,there was no significant difference between the two groups in the scores of physical functioning(PF),role-physical(RP),role-emotional(RE),social functioning(SF),bodily pain(BP),vitality(VT),mental health(MH),general health(GH)and h

关 键 词：不宁腿综合征 加巴喷丁 血液灌流 血液透析 老年 

分 类 号：R692.5[医药卫生—泌尿科学] R741[医药卫生—外科学]