分析氯沙坦联合贝那普利对肾实质性高血压患者血压水平及肾功能的影响  

Analysis of the effects of losartan combined with benazepril on blood pressure and renal function in patients with renal parenchymal hypertension

作　　者：蔡丽 CAI Li(Department of Internal Medicine,Shan County Haijiya Hospital,Heze 274300,China)

机构地区：[1]单县海吉亚医院内科,274300

出　　处：《中国实用医药》2024年第9期80-83,共4页China Practical Medicine

摘　　要：目的分析氯沙坦与贝那普利联合治疗对肾实质性高血压患者血压水平、肾功能的影响。方法选取120例肾实质性高血压患者,按随机数字表法分为对照组及研究组,各60例。对照组给予贝那普利进行治疗,研究组给予氯沙坦与贝那普利联合治疗。比较两组患者治疗前后的血压(舒张压、收缩压)及肾功能指标(24 h尿蛋白定量、血肌酐)水平,不良反应发生情况。结果治疗后,两组患者的舒张压、收缩压均低于本组治疗前,且研究组的舒张压(80.25±3.89)mm Hg(1 mm Hg=0.133 kPa)、收缩压(123.06±12.56)mm Hg比对照组的(87.87±4.93)、(131.46±10.92)mm Hg低,差异有统计学意义(P<0.05)。治疗后,两组24 h尿蛋白定量、血肌酐均低于本组治疗前,且研究组24 h尿蛋白定量(1.23±0.08)g/24 h、血肌酐(127.13±13.62)μmol/L低于对照组的(1.52±0.14)g/24 h、(143.14±16.17)μmol/L,差异有统计学意义(P<0.05)。治疗后,研究组不良反应发生率6.67%比对照组的21.67%低,差异有统计学意义(P<0.05)。结论氯沙坦与贝那普利联合治疗肾实质性高血压患者的效果较好,能有效改善患者的血压指标及肾功能情况,且减少不良反应,有一定临床应用与研究价值。Objective To analyze the effects of losartan combined with benazepril on blood pressure and renal function in patients with renal parenchymal hypertension.Methods A total of 120 patients with renal parenchymal hypertension were selected and divided into a control group and a study group according to random number table method,each with 60 cases.The control group was treated with benazepril,and the study group was treated with losartan and benazepril.The blood pressure(diastolic blood pressure,systolic blood pressure)and renal function indexes(24-h urinary protein quantity,blood creatinine)before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Results After treatment,the diastolic blood pressure and systolic blood pressure in both groups were lower than those before treatment;the study group had diastolic blood pressure of(80.25±3.89)mm Hg(1 mm Hg=0.133 kPa)and systolic blood pressure of(123.06±12.56)mm Hg,which were lower than(87.87±4.93)and(131.46±10.92)mm Hg in the control group;the difference was statistically significant(P<0.05).After treatment,the 24-h urinary protein quantity and serum creatinine in both groups were lower than those before treatment;the study group had 24-h urinary protein quantity of(1.23±0.08)g/24 h and serum creatinine of(127.13±13.62)μmol/L,which were lower than(1.52±0.14)g/24 h and(143.14±16.17)μmol/L in the control group;the difference was statistically significant(P<0.05).After treatment,the incidence of adverse reactions in the study group was 6.67%,which was lower than 21.67%in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of losartan and benazepril in the treatment of patients with renal parenchymal hypertension has a good effect,which can effectively improve the blood pressure index and renal function of patients,and reduce adverse reactions.It has certain clinical application and research value.

关 键 词：氯沙坦 贝那普利 肾实质性高血压 血压水平 肾功能 

分 类 号：R544.1[医药卫生—心血管疾病]