妇科再造丸治疗虚寒性痛经的疗效观察  

Observation on the curative effect of Fu-Ke-Zai-Zao Pill on dysmenorrhea of deficiency cold type

作　　者：吴璇 刘新 宁艳辉 WU Xuan;LIU Xin;NING Yan-hui(General Hospital of Southern Theater Commmand of PLA,Guangzhou 510000,China)

机构地区：[1]中国人民解放军南部战区总医院,510000

出　　处：《中国实用医药》2024年第9期124-127,共4页China Practical Medicine

摘　　要：目的针对虚寒性痛经患者给予妇科再造丸治疗,对治疗效果及安全性予以观察。方法240例虚寒性痛经患者,按照1~240发放数字卡片,单号为观察组,双号为对照组,各120例,分别采取妇科再造丸联合去氧孕烯炔雌醇片(商品名:妈富隆)治疗与单一妈富隆治疗。比较两组疗效、不良反应发生情况及治疗前及治疗后中医证候积分、疼痛程度、血清学指标[前列腺素E_(2)(PGE_(2))、前列腺素F_(2a)(PGF_(2a))]。结果观察组总有效率96.67%高于对照组的81.67%,差异明显(P<0.05)。治疗后,两组小腹冷痛、肛门坠胀、肢体畏寒、腰骶酸痛积分均低于本组治疗前,且观察组小腹冷痛、肛门坠胀、肢体畏寒、腰骶酸痛积分分别为(0.53±0.13)、(0.64±0.13)、(0.53±0.14)、(0.63±0.21)分,低于对照组的(1.32±0.23)、(1.64±0.51)、(1.12±0.26)、(1.22±0.24)分,差异明显(P<0.05)。治疗后,两组视觉模拟评分法(VAS)评分、PGF_(2a)低于本组治疗前,PGE_(2)高于本组治疗前,且观察组VAS评分(1.12±0.52)分、PGF_(2a)(29.03±3.14)pg/ml低于对照组的(2.83±0.57)分、(34.20±3.57)pg/ml,PGE_(2)(28.57±3.85)pg/ml高于对照组的(25.24±3.64)pg/ml,差异明显(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论妇科再造丸应用于虚寒性痛经治疗中,能够促进患者中医证候及血清学指标改善,缓解疼痛,安全有效。Objective To observe the therapeutic effect and safety of Fu-Ke-Zai-Zao Pill on patients with dysmenorrhea of deficiency cold type.Methods A total of 240 patients with dysmenorrhea of deficiency cold type were distributed with digital cards ranging from 1 to 240,with odd number as the observation group and even number as the control group,each with 120 cases.The observation group was treated with Fu-Ke-Zai-Zao Pill and desogestrel and ethinylestradio tablets(trade name:Marvelon),and the control group was treated with Marvelon alone.The efficacy,occurrence of adverse reactions,traditional Chinese medicine syndrome score,pain intensity,serological indexes[prostaglandin E_(2)(PGE_(2)),prostaglandin F2a(PGF2a)]before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 96.67%,which was higher than 81.67%of the control group,and the difference was significant(P<0.05).After treatment,the scores of lower abdominal pain,anal distension,limb chills,and lumbosacral pain in both groups were lower than those before treatment;in the observation group,the scores of lower abdominal pain,anal distension,limb chills and lumbosacral pain were(0.53±0.13),(0.64±0.13),(0.53±0.14)and(0.63±0.21)points,which were lower than(1.32±0.23),(1.64±0.51),(1.12±0.26)and(1.22±0.24)points in the control group;the difference was significant(P<0.05).After treatment,the visual analogue scale(VAS)score and PGF2a in both groups were lower than those before treatment,and PGE_(2) was higher than that before treatment;the observation group had VAS score of(1.12±0.52)points and PGF2a of(29.03±3.14)pg/ml,which were lower than(2.83±0.57)points and(34.20±3.57)pg/ml in the control group;the observation group had higher PGE_(2) of(28.57±3.85)pg/ml than(25.24±3.64)pg/ml in the control group;the difference was significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of Fu-Ke-Zai-Zao Pill in

关 键 词：妇科再造丸 虚寒性痛经 中医证候 疼痛 不良反应 

分 类 号：R271.113[医药卫生—中医妇科学]