妊娠期高血压疾病对母亲及其子代远期健康的影响  

The impact of hypertensive disorders of pregnancy on the long-term health of mother and offspring

作　　者：高迪 隽娟 杨慧霞[1] Gao Di;Juan Juan;Yang Huixia(Department of Obstetrics&Gynecology and Reproductive Medicine,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院妇产生殖医学中心,北京100034

出　　处：《中国医学前沿杂志（电子版）》2024年第4期15-22,共8页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家重点研发计划(2021YFC2700700);中央高水平医院临床研究基金(22cz020401-4811009)。

摘　　要：妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)是一类严重的产科常见并发症,包括妊娠期高血压(gestational hypertension,GH)和子痫前期-子痫(preeclampsia-eclampsia,PE-E)等。近年来,国内外大量研究提示,GH/PE不仅会增加孕产妇及胎儿的不良结局发生风险,同时可能会对母亲及其子代的远期健康产生影响,本文将重点阐述GH/PE对母儿远期健康影响的相关研究进展,从远期慢性高血压、糖尿病及血脂异常、心血管疾病、动脉粥样硬化和心脏功能、肾脏疾病、神经系统疾病、远期死亡风险的角度阐述对母亲远期健康的影响,同时从子代远期心血管代谢风险、神经系统发育、过敏性疾病及死亡风险等角度阐述对子代远期健康的影响。Hypertensive disorders of pregnancy(HDP)are a group of severe common obstetric complications,including gestational hypertension(GH)and preeclampsia-eclampsia(PE-E).In recent years,numerous studies have suggested that GH/PE not only increases the risk of adverse outcomes for pregnant women and their fetuses,but may also impact the long-term health of both mothers and offspring.This article will focus on the research progress regarding the impact of GH/PE on the long-term health of mothers and offspring.It will discuss the long-term effects on maternal health from the perspectives of chronic hypertension,diabetes,dyslipidemia,cardiovascular diseases,atherosclerosis,cardiac function,renal diseases,neurological disorders,and the risk of long-term mortality.Additionally,it may also lead to increased long-term risks of cardiovascular health,neurodevelopment,allergic diseases,and even heightened overall mortality risk in offspring.

关 键 词：妊娠期高血压疾病 妇幼健康 远期影响 

分 类 号：R714.246[医药卫生—妇产科学]