内消瘰疬丸联合西药治疗空洞型非结核分枝杆菌肺病的效果观察  

Observation on the effect of Neixiao Luoli Pills combined with Western medicine in the treatment of cavitary nontuberculous mycobacteria lung disease

作　　者：黄河 谢伟 曾云龙 HUANG He;XIE Wei;ZENG Yunlong(Department of CT,Jiangxi Provincial Chest Hospital,Jiangxi Province,Nanchang 330000,China;Department of Tuberculosis,Jiangxi Provincial Chest Hospital,Jiangxi Province,Nanchang 330000,China;Department of Pharmacy,Jiangxi Provincial Chest Hospital,Jiangxi Province,Nanchang 330000,China)

机构地区：[1]江西省胸科医院CT室,江西南昌330000 [2]江西省胸科医院结核科,江西南昌330000 [3]江西省胸科医院药剂科,江西南昌330000

出　　处：《中国当代医药》2024年第13期67-70,共4页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2023B0712)。

摘　　要：目的探讨利用内消瘰疬丸联合西药治疗空洞型非结核分枝杆菌(NTM)肺病的效果观察,为临床提供治疗新思路。方法回顾性分析2020年7月至2023年4月于江西省胸科医院收治的63例空洞型NTM肺病患者病例,按治疗方案分为西药组(35例)和联合组(28例)。西药组采用基础治疗方案,联合组在基础治疗的方案中加用内消瘰疬丸。观察两组干预3个月后的主要临床表现和胸部CT征象中病灶范围和空洞的变化。结果联合组的咳嗽、咯血的治疗效果优于西药组,总有效率高于西药组,差异有统计学意义(P<0.05),两组的胸闷症状治疗效果和总有效率比较,差异无统计学意义(P>0.05);胸部CT征象中,联合组的胸部CT肺内病灶的吸收情况、空洞病灶闭合情况优于西药组,差异有统计学意义(P<0.05)。结论内消瘰疬丸联合西药治疗NTM肺病能加快临床症状的缓解、缩短病程,胸部CT结果为疗效提供了数据支持,值得临床推广应用。Objective To investigate the effect of Neixiao Luoli Pills combined with western medicine in the treatment of cavitary nontuberculous mycobacterium(NTM)lung disease,and to provide a new therapeutic idea for clinical treatment.Methods Sixty-three patients with cavitary NTM lung disease admitted to Chest Hospital of Jiangxi Province from July 2020 to April 2023 were retrospectively analyzed,and divided into western medicine group(35 cases)and combined group(28 cases)according to treatment regimen.The western medicine group was treated with basic treatment,and the combined group was treated with Neixiao Luoli Pills.The main clinical manifestations and the changes of lesion extent and cavity in chest CT signs were observed in the two groups after intervention for 3 months.Results The treatment effect of cough and hemoptysis in combination group was better than that in western medicine group,and the total effective rate was higher than that in Western medicine group,the difference was statistically significant(P<0.05).There was no significant difference in the treatment effect and total effective rate of chest tightness between the two groups(P>0.05).Among the chest CT signs,the absorption of lung lesions and closure of cavity lesions in the combined group were better than those in the western medicine group,and the differences were statistically significant(P<0.05).Conclusion Neixiao Luoli Pills combined with western medicine in the treatment of NTM lung disease can accelerate the remission of clinical symptoms and shorten the course of disease.The results of chest CT provide data support for the curative effect,which is worthy of clinical promotion and application.

关 键 词：空洞型非结核分枝杆菌 内消瘰疬丸 胸部CT 中西医结合 

分 类 号：R563[医药卫生—呼吸系统]