多光子成像技术及其在化妆品评估中的应用  

Multi-photon imaging technology and its application in cosmetic evaluation

作　　者：张嘉琪 吴凡[1,2] 韩雨晴 刘琦 王俊杰 盘瑶 Jiaqi Zhang;Fan Wu;Yuqing Han;Qi Liu;Junjie Wang;Yao Pan(Department of Cosmetics,School of Light Industry Science and Engineering,Beijing Technology and Business University,Beijing 100048,China;Beijing Key Laboratory of Plant Research and Development,Beijing 100048,China;Beijing EWISH Testing Technology Co.,Ltd,Beijing 100000,China;Beijing Transcend Vivoscope Bio-Technology Co.,Ltd,Beijing 100085,China)

机构地区：[1]北京工商大学轻工科学与工程学院化妆品系,北京100048 [2]北京市植物资源研究开发重点实验室,北京100048 [3]北京颐唯实检测技术有限公司,北京100000 [4]北京超维景生物技术科技有限公司,北京100085

出　　处：《日用化学工业（中英文）》2024年第5期605-613,共9页China Surfactant Detergent & Cosmetics

摘　　要：多光子成像技术是一种观察人体皮肤组织结构的光学成像方法,其原理是利用不同波长的近红外激光使皮肤组织中特定的内源性或外源性荧光物质发出不同的荧光信号,从而观测、区分皮肤不同层的特定组织结构。近年来,该方法开始逐步应用于化妆品的评估中,如评估化妆品紧致抗皱、祛斑美白、透皮吸收的效果等。多光子成像技术能够通过监测皮肤形态或代谢的变化评估化妆品紧致抗皱的作用、定量黑色素分布和含量评估化妆品祛斑美白成分的功效性或判断特定皮肤的类型、可视化化妆品成分透皮吸收的过程评估其功效性或安全性。该方法获得的客观、可视化图像可以为化妆品评估提供定量的数据结果,在皮肤成像领域有着广阔的应用前景,本文综述了这种在体、无创、精准的三维成像方法在化妆品评估中的应用和进展。Multi-photon imaging technology is an optical imaging method that has been used to observe the structure of human skin tissue,which is based on the near-infrared lasers at different wavelengths.Endogenous fluorescent components in specific skin tissues or exogenous fluoresce-labeled substances can emit different fluorescence excited by the light,thereby observing and distinguishing specific tissue structures in different skin layers.In recent years,multi-photon imaging technology has gradually been applied to cosmetic evaluation,such as evaluating the effects of cosmetics on anti-wrinkle,whitening,spot removing and skin penetration.It can evaluate the effect of anti-wrinkle by monitoring the changes of skin metabolism or morphology,classify the specific skin type,evaluate the efficacy of cosmetics whitening ingredients by quantifying the distribution and content of melanin,and visualize the process of skin penetration of cosmetic ingredients.The objective and visual images have broad prospects which can provide quantitative results.This review summarizes the application and progress of this in vivo,non-invasive and accurate three-dimensional method in cosmetic evaluation.

关 键 词：多光子成像技术 化妆品评估 紧致抗皱 祛斑美白 透皮吸收 

分 类 号：TQ658[化学工程—精细化工]