2022年上海市松江区1~30岁健康人群水痘-带状疱疹病毒抗体水平分析  

Antibody levels against varicella-zoster virus in healthy individuals aged 1 to 30 years in Songjiang District of Shanghai in 2022

作　　者：陈文花[1] 沈金花[1] 朱祺[1] 姚红岑 陆红梅[1] CHEN Wenhua;SHEN Jinhua;ZHU Qi;YAO Hongcen;LU Hongmei(Shanghai Songjiang District Center for Diseases Control and Prevention,Shanghai 201620,China)

机构地区：[1]上海市松江区疾病预防控制中心,上海201620

出　　处：《上海预防医学》2024年第4期337-341,共5页Shanghai Journal of Preventive Medicine

基　　金：上海市松江区三年行动计划项目——松江区免疫规划体系建设(20GWTX25)。

摘　　要：【目的】了解上海市松江区1~30岁健康人群水痘-带状疱疹病毒(VZV)抗体水平,为健康人群水痘免疫策略制定提供依据。【方法】采用多阶段分层随机抽样方法于2022年7—9月在松江区抽取6个村居委,招募1~30岁健康人群采集静脉血3~5 mL,采用酶联免疫吸附试验(ELISA)检测VZV IgG抗体水平,分析比较VZV IgG抗体阳性率和抗体几何平均浓度(GMC)。【结果】本研究共纳入对象315例,平均年龄(10.97±8.38)岁,其中男性165例[年龄(11.00±8.52)岁],女性150例[年龄(10.96±8.25)岁]。共采集315例1~30岁健康人群血样,VZV IgG总体抗体阳性率为55.24%(174/315),GMC为99.73 mIU·mL^(-1),其中VZV IgG抗体阳性者GMC为413.11 mIU·mL^(-1)。不同年龄组VZV IgG抗体阳性率和GMC范围分别为13.33%~86.67%和16.36~355.14 mIU·mL^(-1),其中20~30岁年龄组GMC最高(355.14 mIU·mL^(-1)),19岁以下人群中5~岁和15~岁年龄组GMC水平较高,分别为132.41、138.12 mIU·mL^(-1);接种1剂次水痘疫苗者VZV IgG抗体阳性率为38.40%,GMC为53.28 mIU·mL^(-1),接种2剂次水痘疫苗者为63.49%,GMC为130.79 mIU·mL^(-1)。多因素分析显示,职业类型是健康人群VZV IgG抗体阳性率危险因素(OR=2.540);有2剂次水痘免疫史者,距末次水痘接种时间是健康人群VZV IgG抗体阳性率的保护因素(OR=0.315)。【结论】上海市松江区健康人群VZV IgG抗体总体水平偏低,应继续加强水痘2剂次免疫规划程序的实施,提高易感人群水痘疫苗接种率。[Objective]To determine the antibody levels of varicella-zoster virus(VZV)in healthy individuals aged 1 to 30 years in Songjiang District of Shanghai,and to provide evidence for further development of varicella immunization strategies for healthy population.[Methods]Six village committees were selected in Songjiang District through multi-stage stratified random sampling method from July to September 2022.Healthy individuals aged 1 to 30 years old in these villages were recruited and 3‒5 mL of venous blood was collected.Anti-VZV IgG antibody was tested by ELISA.Positive rate of anti-VZV IgG antibody and geometric mean concentration(GMC)were determined.[Results]A total of 315 healthy individuals aged(10.97±8.38)years were included in this study,of which 165 were males aged(11.00±8.52)years and 150 were females aged(10.96±8.25)years.Blood samples were collected and tested for anti-VZV IgG antibody,with the overall positive rate of 55.24%(174/315).The GMC was calculated to be 99.73 mIU·mL^(-1),with the GMC in those tested positive for anti-VZV IgG antibody of 413.11 mIU·mL^(-1).The positive rate of anti-VZV IgG antibody and GMCs across age groups ranged between 13.33%‒86.67%and 16.36‒355.14 mIU·mL^(-1),respectively.The highest GMC was found in the group of 20‒30 years old(355.14 mIU·mL^(-1)),followed by 132.41 mIU·mL^(-1) in the group of 5‒years old and 138.12 mIU·mL^(-1) in the group of 15‒years old.Moreover,the positive rate was 38.47%in the group with 1-dose varicella vaccine and 63.49%in the group with 2 doses,while the GMC were 53.28 mIU·mL^(-1) and 130.79 mIU·mL^(-1) in these two groups,respectively.Multivariable analysis revealed that occupation was a risk factor associated with anti-VZV IgG antibody(OR=2.540).Stratified analysis by varicella immunization history showed that among 2-dose vaccination group,time interval since the last dose was a protective factor(OR=0.315).[Conclusions]The overall positive rate of anti-VZV IgG antibody in healthy population in Songjiang District of Shangh

关 键 词：水痘-带状疱疹病毒 水痘疫苗 IGG抗体 抗体阳性率 

分 类 号：R186[医药卫生—流行病学]