2019—2023年上海市浦东新区12岁以下儿童急性呼吸道感染的检测情况分析  

Analysis of detection of acute respiratory infection in children under 12 years old in Pudong New Area,Shanghai from 2019 to 2023

作　　者：袁洋[1] 张露 李竹雲 张悦 霍雨佳 陈佳亮 刘青[1] 邹文玮[1] 赵冰[1] 郝莉鹏 潘丽峰[1,3] YUAN Yang;ZHANG Lu;LI Zhuyun;ZHANG Yue;HUO Yujia;CHEN Jialiang;LIU Qing;ZOU Wenwei;ZHAO Bing;HAO Lipeng;PAN Lifeng(Shanghai Pudong New Area Center for Disease Control and Prevention,Shanghai 200136,China;School of Public Health,Dali University,Dali,Yunnan 671000,China;Fudan University Pudong Institute of Preventive Medicine,Shanghai 200136,China)

机构地区：[1]上海市浦东新区疾病预防控制中心,上海200136 [2]大理大学公共卫生学院,云南大理671000 [3]复旦大学浦东预防医学研究院,上海200136

出　　处：《上海预防医学》2024年第4期342-347,共6页Shanghai Journal of Preventive Medicine

基　　金：上海市卫生健康委员会卫生行业临床研究专项项目(202240094);上海市浦东新区卫生健康委员会面上项目(PW2020A-75)。

摘　　要：【目的】了解2019—2023年上海市浦东新区12岁以下儿童急性呼吸道感染(ARTI)情况。【方法】收集2019—2023年上海市浦东新区3家哨点医院12岁以下儿童ARTI样本,用微流体芯片检测流感病毒、人腺病毒、副流感病毒、呼吸道合胞病毒、人肠道病毒/鼻病毒、人肺病毒、人博卡病毒、冠状病毒(229E、HKU1、NL63和OC43)、新型冠状病毒等42种呼吸道感染病原体。分析非药物干预措施前(2019.12—2020.1)、非药物干预措施期(2020.2—2022.12)和非药物干预措施后(2023.1—2023.6)浦东新区门急诊患儿和住院患儿的ARTI情况。【结果】2019—2023年共采集样本1770份,检出各类病原体445份,检出率为25.14%(445/1770)。研究期间主要的检出病原体为流感病毒(8.70%,154/1770)、呼吸道合胞病毒(4.41%,78/1770)、人肠道病毒/鼻病毒(2.66%,47/1770)、人腺病毒(2.49%,44/1770)、副流感病毒(2.20%,39/1770)。非药物干预措施前门诊患儿以感染流感、副流感病毒和呼吸道合胞病毒为主,检出率分别为8.09%、4.49%和4.04%;住院患儿以感染流感、呼吸道合胞病毒和副流感病毒为主,检出率分别为4.49%、3.82%和3.15%。非药物干预措施期,门诊患儿样本以流感、鼻病毒和呼吸道合胞病毒检出为主,检出率分别为4.04%、3.60%和2.47%;住院患儿样本以呼吸道合胞病毒、鼻病毒和流感病毒检出为主,检出率分别为3.60%、2.02%和1.80%。非药物干预措施后,流感、鼻病毒和呼吸道合胞病毒为门诊患儿主要检出病原体,检出率分别为9.89%、2.92%和2.02%;流感、呼吸道合胞病毒和鼻病毒为住院患儿主要检出病原体,检出率分别为6.29%、1.57%和1.35%。【结论】儿童ARTI相关病原体的流行受到非药物干预措施的影响。[Objective]To investigate the impact of acute respiratory infections in children under 12 years old in Pudong New Area,Shanghai from 2019 to 2023.[Methods]Acute respiratory infection samples of children under 12 years old from three sentinel hospitals in Pudong New Area,Shanghai from 2019 to 2023 were collected,and 42 respiratory infection pathogens,including influenza virus,adenovirus,parainfluenza virus,respiratory syncytial virus,human enterovirus/rhinovirus,human pulmonary virus,human bokavirus,coronavirus(229E,HKU1,NL63 and OC43),and novel coronavirus,were detected with microfluidic chips.The situation of acute respiratory infections among outpatient and inpatient children in this area was analyzed for the before the implementation of non pharmacological intervention measures(2019.12‒2020.1),during the period of non pharmacological intervention measures(2020.2‒2022.12),and after non pharmacological intervention measures(2023.1‒2023.6).[Results]From 2019 to 2023,a total of 1770 samples were collected,and 445 pathogens were detected,with a detection rate of 25.14%(445/1770).The main pathogens detected during the study period were influenza virus:8.70%(154/1770),respiratory syncytial virus:4.41%(78/1770),human enterovirus/rhinovirus:2.66%(47/1770),human adenovirus:2.49%(44/1770),and parainfluenza virus:2.20%(39/1770).Before the implementation of non pharmacological intervention measures,outpatients were primarily infected with influenza,parainfluenza virus,and respiratory syncytial virus,with detection rates of 8.09%,4.49%,and 4.04%,respectively;inpatients were mainly infected with influenza,respiratory syncytial virus,and parainfluenza virus,with detection rates of 4.49%,3.82%,and 3.15%,respectively.During the period of non pharmacological intervention measures,influenza,rhinovirus and respiratory syncytial virus were the main viruses detected in the samples of outpatient children,with detection rates of 4.04%,3.60%,and 2.47%,respectively;inpatient samples mainly detected respiratory syncytial virus,rhin

关 键 词：急性呼吸道感染 儿童 呼吸道病原体 上海 

分 类 号：R179[医药卫生—妇幼卫生保健]