OCTA定量分析儿童阻塞性睡眠呼吸暂停综合征患者黄斑区微循环变化  

Quantitative Analysis of Macular Microcirculation Changes in Children with Obstructive Sleep Apnea Syndrome Using OCTA

作　　者：吴晶晶[1] 黄翠婷 张招德 王雨晴 陈艳榕 张晋锋 WU Jingjing;HUANG Cuiting;ZHANG Zhaode;WANG Yuqing;CHEN Yanrong;ZHANG Jinfeng(Ningde Municipal Hospital of Ningde Normal University,Ningde 352100,China)

机构地区：[1]宁德师范学院附属宁德市医院眼科,宁德352100

出　　处：《宁夏医科大学学报》2024年第3期255-258,共4页Journal of Ningxia Medical University

基　　金：福建省自然科学基金项目(2021J011163)。

摘　　要：目的基于光学相干断层扫描血管成像(optical coherence tomography angiography,OCTA)探讨儿童阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)对黄斑区血管长度、血流密度、黄斑区中心凹无血管区面积(foveal avascular zone,FAZ)大小的影响。方法收集2020年1月至2021年12月就诊于宁德师范学院附属宁德市医院耳鼻咽喉科儿童患者51例为实验组,51例正常儿童为对照组。所有患者行身高、裸眼视力、屈光度、矫正视力检查后,行眼科检查。观察两组黄斑区浅层毛细血管长度密度(vascular length density,VLD)、血流灌注密度(vascular perfusion density,VPD)和黄斑区FAZ。结果两组患者黄斑浅层VLD1、VLD3、VLD4比较差异无统计学意义(P>0.05),而实验组VLD2低于对照组(t=-3.334,P=0.01)。两组患者黄斑浅层的差异VPD3、FAZ比较差异均无统计学意义(P均>0.05),实验组VPD1、VPD2均小于对照组(P均<0.001),实验组VPD4大于对照组(P<0.001)。结论OCTA检查可定量分析儿童OSAS患者黄斑区微循环变化,并且儿童OSAS患者的黄斑区微循环变化是判断视网膜缺氧的早期指标。Objective To investigate the effects of optical coherence tomography angiography(OCTA)on the length of blood vessels,blood flow density,and size of the focal avascular zone(FAZ)in the macular region of pediatric obstructive sleep apnea syndrome(OSAS).Methods Fifty-one pediatric patients who visited the Department of Otolaryngology at Ningde Municipal Hospital of Ningde Normal University from January 2020 to December 2021 were collected as experimental group,and 51 normal children were chosen as a control group.After undergoing height,naked eye vision,refractive index,and corrected vision examinations for all patients,pediatric patients would be identified and undergo ophthalmic examinations simultaneously.The differences in superficial capillary vascular length density(VLD),blood perfusion density(VPD),and macular area FAZ between two groups were observed.Results There was no significant difference in VLD1,VLD3 and VLD4 between the two groups(P>0.05).VLD2 was higher in the experimental group than in the control group(t=-3.334,P=0.01).There was no significant difference in VPD3 and FAZ in the superficial inacula between the two groups(P all>0.05).VPD1 and VPD2 of the experimental group were smaller than the control group(P all<0.001),while VPD4 of the experimental group was larger than the control group(P<0.001).Conclusion OCTA examination could quantitatively analyze the microcirculation changes in the macular area of children with OSAS,and the microcirculation changes in the macular area of children with OSAS were an early indicator of retinal hypoxia.

关 键 词：阻塞性睡眠呼吸暂停综合征 光学相干断层扫描血管成像 黄斑血流 

分 类 号：R766[医药卫生—耳鼻咽喉科]